TY - JOUR
T1 - In vivo upregulation of interleukin-4 is one mechanism underlying the immunoregulatory effects of 1,25-dihydroxyvitamin D31
AU - Cantorna, Margherita T.
AU - Humpal-Winter, Jean
AU - DeLuca, Hector F.
N1 - Funding Information:
1This work was supported in part by Program Project Grant DK14881 from the National Institutes of Health, a fund from the National Foundation for Cancer Research, and a fund from the Wisconsin Alumni Research Foundation.
PY - 2000/5/1
Y1 - 2000/5/1
N2 - The active form of vitamin D (1,25-(OH)2D3) is a potent immune system regulator. In vivo the oral administration of 1,25-(OH)2D3 completely prevents experimental autoimmune encephalomyelitis (EAE), significantly prolongs allograft survival, and prevents collagen-induced arthritis. 1,25- (OH)2D3 given to mice increased IL-4 protein and transcript levels. We have now tested the efficacy of 1,25-(OH)2D3 on EAE development and allograft survival in IL-4-deficient [knockout (ko)] mice. 1,25-(OH)2D3 was found to be much less effective in the absence of IL-4, suggesting that IL-4 production is a significant factor in the action of 1,25-(OH)2D3 on the immune system. (C) 2000 Academic Press.
AB - The active form of vitamin D (1,25-(OH)2D3) is a potent immune system regulator. In vivo the oral administration of 1,25-(OH)2D3 completely prevents experimental autoimmune encephalomyelitis (EAE), significantly prolongs allograft survival, and prevents collagen-induced arthritis. 1,25- (OH)2D3 given to mice increased IL-4 protein and transcript levels. We have now tested the efficacy of 1,25-(OH)2D3 on EAE development and allograft survival in IL-4-deficient [knockout (ko)] mice. 1,25-(OH)2D3 was found to be much less effective in the absence of IL-4, suggesting that IL-4 production is a significant factor in the action of 1,25-(OH)2D3 on the immune system. (C) 2000 Academic Press.
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U2 - 10.1006/abbi.2000.1765
DO - 10.1006/abbi.2000.1765
M3 - Article
C2 - 10775452
AN - SCOPUS:0034193477
SN - 0003-9861
VL - 377
SP - 135
EP - 138
JO - Archives of Biochemistry and Biophysics
JF - Archives of Biochemistry and Biophysics
IS - 1
ER -