Incidence and Risk Factors for Genitourinary Tract Injury Within 1Year After Surgery for Pelvic Organ Prolapse

Importance The rate of genitourinary tract injury (GUTI) following pelvic organ prolapse (POP) surgery is presently ill-defined and based on relatively small trials with short follow-up time. Given the potential for higher risk of injury with POP, a better understanding of this type of injury is important for patient counseling. Objectives The objective of this study was to identify the incidence and risk factors of GUTI related to POP surgery. Study Design Women undergoing POP surgery between 2010 and 2019 were identified using Current Procedural Terminology codes in the Premier Healthcare Database. The primary outcome was GUTI, defined as bladder or ureteral injury, and vesicovaginal or ureterovaginal fistula within 1year of surgery. Genitourinary tract injury was identified using International Classification of Diseases and Current Procedural Terminology codes. Patients were divided into those with and without GUTI. Differences between groups were evaluated using the Student t test, Wilcoxon rank-sum test, and Fisher exact test as appropriate. Multivariable logistic regression was used to evaluate the independent predictors of GUTI. Results One hundred thirty-nine thousand one hundred fifty-eight surgical procedures for POP were captured between 2010 and 2019. The rate of GUTI was 1.10%: 0.48% bladder, 0.64% ureteral injuries, and 0.01% fistulas. The most significant variables associated with any GUTI were as follows: adhesiolysis (adjusted odds ratio [aOR],2.64; 95% confidence interval [CI], 1.07–6.51), blood transfusion (aOR,3.67; 95% CI, 1.34–10.04), and low-volume surgeons (<12 cases per year) (aOR,1.68; 95% CI, 1.60–1.77), nonurologic or gynecologic surgeon specialty (aOR,1.62; 95% CI, 1.49–2.00), and uterosacral suspension (aOR,1.30; 95% CI, 1.13–1.49). Conclusions The rate of GUTI following POP surgery is lower than has previously been reported. Surgeon experience and specialty and surgical approach may affect GUTI incidence.