Incidence, predictors, and outcome of early seizures after mechanical thrombectomy

Mohammad Anadani, Alain Zingraff Lekoubou Looti, Eyad Almallouhi, Ali Alawieh, Arindam Chatterjee, Jan Vargas, Alejandro M. Spiotta

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Objective: Despite the wide utilization of mechanical thrombectomy (MT) for acute ischemic stroke treatment, little is known about the incidence of early post-thrombectomy seizures, its predictors, and association with long-term outcome. Methods: Using a prospective registry of mechanical thrombectomy in ischemic stroke between January 2013 and July 2017, we identified patients who developed a seizure within 7 days (early seizure) of qualifying event. Backward stepwise regression analysis was used to assess independent predictors of seizure occurrence and the association between seizure and functional outcome (modified Rankin scale of 0–2 vs. ≥3). Results: A total of 459 patients were included in the final analysis. Mean age was 67.5 (SD 15.1), and 49.9% of patients were female. Successful recanalization (TICI≥2B) was achieved in 92.8% of patients. Eleven (2.4%) patients developed at least one seizure. Only an Alberta Stroke Program Early CT (ASPECT) score of <6 was independently associated with the occurrence of early seizures [Odds ratio, 95% confidence interval: 8.188, (2.219–30.214); P =.002]. On multivariate analysis, early seizures were associated with 90-day mortality rate [OR,6.487; 95% confidence interval, (1.481–28.405); P =.013] and poor functional outcome (OR, 4.7; 95% confidence interval (1.08–20.83); p =.039). Conclusion: In the studied cohort, 2.4% of ischemic stroke patients treated with MT developed at least one seizure within 7 days of stroke onset. A low ASPECT score was associated with the occurrence of early seizures. The occurrence of seizures was associated with 90-day mortality and poor functional outcome.

Original languageEnglish (US)
Pages (from-to)235-239
Number of pages5
JournalJournal of the neurological sciences
StatePublished - Jan 15 2019

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology


Dive into the research topics of 'Incidence, predictors, and outcome of early seizures after mechanical thrombectomy'. Together they form a unique fingerprint.

Cite this