TY - JOUR
T1 - Increased food intake after type A but not type B cholecystokinin receptor blockade
AU - Corwin, R. L.
AU - Gibbs, J.
AU - Smith, G. P.
N1 - Funding Information:
This research was supported by MH40010 and MH00149. Dr. Cor-win was supported, in part, by Training Grant MH18390. The two antagonists were generously provided by Merck Sharp and Dohme, Rahway, NJ. The authors thank Richard D. Shindledecker for advice about statistical analysis and about the gastric acid measurements. We also thank Danielle Greenberg for timely instruction in SAS.
PY - 1991/7
Y1 - 1991/7
N2 - To assess the role of cholecystokinin (CCK) receptors in mediating the satiating effect of an oral preload, overnight food-deprived rats (n=7) were given access to a high-carbohydrate liquid diet for 40 min. At the end of 40 min, food was removed and rats were injected subcutaneously (SC) with devazepide (DVZ; 1 ng/kg-1 mg/kg), an antagonist selective for the CCK-A receptor, or its vehicle, 0.5% carboxymethylcellulose (CMC). Thirty min after injection, rats were given access to the same liquid food for 60 min. DVZ increased food intake significantly. Furthermore, the effectiveness of a very low dose of DVZ (10 ng/kg) is strong evidence that the effect of DVZ was specific for CCK-A receptors. Three of the rats that increased food intake after DVZ were also tested with L-365,260, an antagonist selective for the CCK-B receptor (10 ng/kg-100 μg/kg). L365,260 did not increase food intake significantly. These results confirm and extend previous reports that CCK-A receptor blockade increases food intake after an oral preload. They do not, however, demonstrate a role for the CCK-B receptor in mediating the satiating effect of ingested food under the same experimental conditions.
AB - To assess the role of cholecystokinin (CCK) receptors in mediating the satiating effect of an oral preload, overnight food-deprived rats (n=7) were given access to a high-carbohydrate liquid diet for 40 min. At the end of 40 min, food was removed and rats were injected subcutaneously (SC) with devazepide (DVZ; 1 ng/kg-1 mg/kg), an antagonist selective for the CCK-A receptor, or its vehicle, 0.5% carboxymethylcellulose (CMC). Thirty min after injection, rats were given access to the same liquid food for 60 min. DVZ increased food intake significantly. Furthermore, the effectiveness of a very low dose of DVZ (10 ng/kg) is strong evidence that the effect of DVZ was specific for CCK-A receptors. Three of the rats that increased food intake after DVZ were also tested with L-365,260, an antagonist selective for the CCK-B receptor (10 ng/kg-100 μg/kg). L365,260 did not increase food intake significantly. These results confirm and extend previous reports that CCK-A receptor blockade increases food intake after an oral preload. They do not, however, demonstrate a role for the CCK-B receptor in mediating the satiating effect of ingested food under the same experimental conditions.
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U2 - 10.1016/0031-9384(91)90529-W
DO - 10.1016/0031-9384(91)90529-W
M3 - Article
C2 - 1946726
AN - SCOPUS:0025737031
SN - 0031-9384
VL - 50
SP - 255
EP - 258
JO - Physiology and Behavior
JF - Physiology and Behavior
IS - 1
ER -