TY - JOUR
T1 - Increased hippocampal CA1 cerebral blood volume in schizophrenia
AU - Talati, Pratik
AU - Rane, Swati
AU - Kose, Samet
AU - Blackford, Jennifer Urbano
AU - Gore, John
AU - Donahue, Manus J.
AU - Heckers, Stephan
PY - 2014
Y1 - 2014
N2 - Hippocampal hyperactivity has been proposed as a biomarker in schizophrenia. However, there is a debate whether the CA1 or the CA2/3 subfield is selectively affected. We studied 15 schizophrenia patients and 15 matched healthy control subjects with 3T steady state, gadolinium-enhanced, absolute cerebral blood volume (CBV) maps, perpendicular to the long axis of the hippocampus. The subfields of the hippocampal formation (subiculum, CA1, CA2/3, and hilus/dentate gyrus) were manually segmented to establish CBV values. Comparing anterior CA1 and CA2/3 CBV between patients and controls revealed a significant subfield-by-diagnosis interaction. This interaction was due to the combined effect of a trend of increased CA1 CBV (p =.06) and non-significantly decreased CA2/3 CBV (p = 0.14) in patients relative to healthy controls. These results support the emerging hypothesis of increased hippocampal activity as a biomarker of schizophrenia and highlight the importance of subfield-level investigations.
AB - Hippocampal hyperactivity has been proposed as a biomarker in schizophrenia. However, there is a debate whether the CA1 or the CA2/3 subfield is selectively affected. We studied 15 schizophrenia patients and 15 matched healthy control subjects with 3T steady state, gadolinium-enhanced, absolute cerebral blood volume (CBV) maps, perpendicular to the long axis of the hippocampus. The subfields of the hippocampal formation (subiculum, CA1, CA2/3, and hilus/dentate gyrus) were manually segmented to establish CBV values. Comparing anterior CA1 and CA2/3 CBV between patients and controls revealed a significant subfield-by-diagnosis interaction. This interaction was due to the combined effect of a trend of increased CA1 CBV (p =.06) and non-significantly decreased CA2/3 CBV (p = 0.14) in patients relative to healthy controls. These results support the emerging hypothesis of increased hippocampal activity as a biomarker of schizophrenia and highlight the importance of subfield-level investigations.
UR - https://www.scopus.com/pages/publications/84907338236
UR - https://www.scopus.com/inward/citedby.url?scp=84907338236&partnerID=8YFLogxK
U2 - 10.1016/j.nicl.2014.07.004
DO - 10.1016/j.nicl.2014.07.004
M3 - Article
C2 - 25161901
AN - SCOPUS:84907338236
SN - 2213-1582
VL - 5
SP - 359
EP - 364
JO - NeuroImage: Clinical
JF - NeuroImage: Clinical
ER -