Increased incidence of the Hfe mutation in amyotrophic lateral sclerosis and related cellular consequences

Xin Sheng Wang, Sang Lee, Zachary Simmons, Philip Boyer, Kevin Scott, Wenlei Liu, James Connor

Research output: Contribution to journalArticlepeer-review

104 Scopus citations


The etiology of amyotrophic lateral sclerosis (ALS) is unknown. The presence of mutations in the superoxide dismutase gene (SOD1) has led to theories regarding a role for oxidative stress in the pathogenesis of this disease. A primary cause of oxidative stress is perturbations in cellular iron homeostasis. Cellular iron mismanagement and oxidative stress are associated with a number of neurodegenerative diseases. One mechanism by which cells fail to properly regulate their iron status is through a mutation in the Hfe gene. Mutations in the Hfe gene are associated with the iron overload disease, hemochromatosis. In the current study, 31% of patients with sporadic ALS carried a mutation in the Hfe gene, compared to only 14% of patients without identifiable neuromuscular disease, or with neuromuscular diseases other than ALS (p<0.005). To determine the cellular consequences of carrying an Hfe mutation, a human neuronal cell line was transfected with genes carrying the Hfe mutation. The presence of the Hfe mutation disrupted expression of tubulin and actin at the protein levels potentially consistent with the disruption of axonal transport seen in ALS and was also associated with a decrease in CuZnSOD1 expression. These data provide compelling evidence for a role for the Hfe mutation in etiopathogenesis of ALS and warrant further investigation.

Original languageEnglish (US)
Pages (from-to)27-33
Number of pages7
JournalJournal of the neurological sciences
Issue number1
StatePublished - Dec 15 2004

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology


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