Increased Prolactin Levels During Reserpine Treatment of Hypertensive Patients

Peter A. Lee; Michael R. Kelly; John D. Wallin

doi:10.1001/jama.1976.03260470034022

Increased Prolactin Levels During Reserpine Treatment of Hypertensive Patients

Peter A. Lee
, Michael R. Kelly
, John D. Wallin

Department of Pediatrics

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Serum prolactin levels are significantly greater among hypertensive patients receiving reserpine as compared to levels six weeks after discontinuing the treatment (P <.005). This association between regular, longterm reserpine use and greater prolactin levels may be clinically significant, since an increased incidence of breast cancer has been reported among hypertensive patients receiving reserpine.

Original language	English (US)
Pages (from-to)	2316-2317
Number of pages	2
Journal	JAMA: The Journal of the American Medical Association
Volume	235
Issue number	21
DOIs	https://doi.org/10.1001/jama.1976.03260470034022
State	Published - May 24 1976

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

General Medicine

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10.1001/jama.1976.03260470034022

Cite this

@article{21c75f30b1334a9e83eadc1f28d3c65b,

title = "Increased Prolactin Levels During Reserpine Treatment of Hypertensive Patients",

abstract = "Serum prolactin levels are significantly greater among hypertensive patients receiving reserpine as compared to levels six weeks after discontinuing the treatment (P <.005). This association between regular, longterm reserpine use and greater prolactin levels may be clinically significant, since an increased incidence of breast cancer has been reported among hypertensive patients receiving reserpine.",

author = "Lee, \{Peter A.\} and Kelly, \{Michael R.\} and Wallin, \{John D.\}",

note = "Funding Information: lanttionsformayneoplasticnotbeachangeuniversalorgrowthstimu¬ butrathermaybeoneofseveralpos¬ sibleetiologicfactorsactingaloneor inconjunctionwithotheragents. Wehaveevaluatedtherelationship betweenreserpineprolactinandpri¬ marilyamongpostmenopausalwom¬ en.Sincethehormonalprofileinthis groupdiffersmarkedlyfromthatin premenopausal women, implications concerningthislattergroupcannot bemade.Becauseoflimitednumbers, the significance of increased LH con¬ centrationsamongthemencannotbe interpreted. be ofintheMechanismsotherthan prolactinmayof importance to relationship reserpinetherapy breast cancer. If the pattern of in¬ creasedLHconcentrationscouldbe shown to beconsistent,onecould speculate concerningtheroleofLH and breast cancer. In this study, the sinceentirethegroupcouldnotbewomencompared,had elevated postmenopausaldue to lack of gonadotropins suppression bygonadalsteroids. This study was supported through funds pro¬ videdbytheBureauofMedicineandSurgery, USNavyDepartment,forCI5-48-487C. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.",

year = "1976",

month = may,

day = "24",

doi = "10.1001/jama.1976.03260470034022",

language = "English (US)",

volume = "235",

pages = "2316--2317",

journal = "JAMA: The Journal of the American Medical Association",

issn = "0098-7484",

publisher = "American Medical Association",

number = "21",

}

TY - JOUR

T1 - Increased Prolactin Levels During Reserpine Treatment of Hypertensive Patients

AU - Lee, Peter A.

AU - Kelly, Michael R.

AU - Wallin, John D.

N1 - Funding Information: lanttionsformayneoplasticnotbeachangeuniversalorgrowthstimu¬ butrathermaybeoneofseveralpos¬ sibleetiologicfactorsactingaloneor inconjunctionwithotheragents. Wehaveevaluatedtherelationship betweenreserpineprolactinandpri¬ marilyamongpostmenopausalwom¬ en.Sincethehormonalprofileinthis groupdiffersmarkedlyfromthatin premenopausal women, implications concerningthislattergroupcannot bemade.Becauseoflimitednumbers, the significance of increased LH con¬ centrationsamongthemencannotbe interpreted. be ofintheMechanismsotherthan prolactinmayof importance to relationship reserpinetherapy breast cancer. If the pattern of in¬ creasedLHconcentrationscouldbe shown to beconsistent,onecould speculate concerningtheroleofLH and breast cancer. In this study, the sinceentirethegroupcouldnotbewomencompared,had elevated postmenopausaldue to lack of gonadotropins suppression bygonadalsteroids. This study was supported through funds pro¬ videdbytheBureauofMedicineandSurgery, USNavyDepartment,forCI5-48-487C. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.

PY - 1976/5/24

Y1 - 1976/5/24

N2 - Serum prolactin levels are significantly greater among hypertensive patients receiving reserpine as compared to levels six weeks after discontinuing the treatment (P <.005). This association between regular, longterm reserpine use and greater prolactin levels may be clinically significant, since an increased incidence of breast cancer has been reported among hypertensive patients receiving reserpine.

AB - Serum prolactin levels are significantly greater among hypertensive patients receiving reserpine as compared to levels six weeks after discontinuing the treatment (P <.005). This association between regular, longterm reserpine use and greater prolactin levels may be clinically significant, since an increased incidence of breast cancer has been reported among hypertensive patients receiving reserpine.

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U2 - 10.1001/jama.1976.03260470034022

DO - 10.1001/jama.1976.03260470034022

M3 - Article

C2 - 131202

AN - SCOPUS:0017314633

SN - 0098-7484

VL - 235

SP - 2316

EP - 2317

JO - JAMA: The Journal of the American Medical Association

JF - JAMA: The Journal of the American Medical Association

IS - 21

ER -

Increased Prolactin Levels During Reserpine Treatment of Hypertensive Patients

Abstract

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