TY - JOUR
T1 - Increasing Life Expectancy in Patients with Genitourinary Malignancies
T2 - Impact of Treatment Burden on Disease Management and Quality of Life
AU - St-Laurent, Marie Pier
AU - Bochner, Bernard
AU - Catto, James
AU - Davies, Benjamin J.
AU - Fankhauser, Christian Daniel
AU - Garg, Tullika
AU - Hamilton-Reeves, Jill
AU - Master, Viraj
AU - Jensen, Bente T.
AU - Lauridsen, Susanne V.
AU - Wulff-Burchfield, Elizabeth
AU - Psutka, Sarah P.
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2024
Y1 - 2024
N2 - Background and objective: Treatment burden refers to the overall impact of medical treatments on a patient's well-being and daily life. Our objective is to evaluate the impact of treatment burden on quality of life (QoL) in patients with genitourinary (GU) malignancies, highlighting the importance of patient-reported outcomes (PROs) in clinical trials to inform treatment decisions and improve patient care. Methods: We conducted a narrative review of clinical trials focused on GU malignancy (prostate, bladder, and kidney) between January 2000 and June 2024, analyzing related PROs and findings regarding treatment burden. Key findings and limitations: Recent landmark clinical trials demonstrate significant improvements in overall survival across GU malignancies with novel therapies. However, the reporting of QoL outcomes in these trials is often inadequate, with many lacking comprehensive data or long-term impact. Current publications are increasingly evaluating treatment burden and its impact on patient well-being as a critical outcome, but most clinical trials to date have failed to assess treatment burden across key domains including financial, time and travel, and medication management. Conclusions and clinical implications: While advancements in treatment have extended longevity in patients with GU malignancies, the treatment burden associated with the receipt of novel agents and its implications for QoL remain inadequately uncharacterized.
AB - Background and objective: Treatment burden refers to the overall impact of medical treatments on a patient's well-being and daily life. Our objective is to evaluate the impact of treatment burden on quality of life (QoL) in patients with genitourinary (GU) malignancies, highlighting the importance of patient-reported outcomes (PROs) in clinical trials to inform treatment decisions and improve patient care. Methods: We conducted a narrative review of clinical trials focused on GU malignancy (prostate, bladder, and kidney) between January 2000 and June 2024, analyzing related PROs and findings regarding treatment burden. Key findings and limitations: Recent landmark clinical trials demonstrate significant improvements in overall survival across GU malignancies with novel therapies. However, the reporting of QoL outcomes in these trials is often inadequate, with many lacking comprehensive data or long-term impact. Current publications are increasingly evaluating treatment burden and its impact on patient well-being as a critical outcome, but most clinical trials to date have failed to assess treatment burden across key domains including financial, time and travel, and medication management. Conclusions and clinical implications: While advancements in treatment have extended longevity in patients with GU malignancies, the treatment burden associated with the receipt of novel agents and its implications for QoL remain inadequately uncharacterized.
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U2 - 10.1016/j.eururo.2024.11.026
DO - 10.1016/j.eururo.2024.11.026
M3 - Review article
C2 - 39706786
AN - SCOPUS:85212631651
SN - 0302-2838
JO - European Urology
JF - European Urology
ER -
