Induction of senescence by adenosine suppressing the growth of lung cancer cells

Dongqin Yang; Junyao Song; Lijun Wu; Yunfang Ma; Chunhua Song; Sinisa Dovat; Tomoyuki Nishizaki; Jie Liu

doi:10.1016/j.bbrc.2013.09.030

Induction of senescence by adenosine suppressing the growth of lung cancer cells

Dongqin Yang, Junyao Song, Lijun Wu, Yunfang Ma, Chunhua Song, Sinisa Dovat, Tomoyuki Nishizaki, Jie Liu

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Extracellular adenosine is well reported to suppress tumor growth by induction of apoptosis. However, in this study we found that adenosine treatment results in cellular senescence in A549 lung cancer cells both in vitro and in vivo; adenosine induces cell cycle arrest and senescence in a p53/p21 dependent manner; adenosine elevates the level of phosphor-γH2AX, pCHK2 and pBRCA1, the markers for prolonged DNA damage response which are likely responsible for initiating the cellular senescence. Our study first demonstrates that adenosine suppresses growth of cancer cells by inducing senescence and provides additional evidence that adenosine could act as an effective anticancer agent for targeted cancer therapy.

Original language	English (US)
Pages (from-to)	62-67
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	440
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2013.09.030
State	Published - Oct 11 2013

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbrc.2013.09.030

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title = "Induction of senescence by adenosine suppressing the growth of lung cancer cells",

abstract = "Extracellular adenosine is well reported to suppress tumor growth by induction of apoptosis. However, in this study we found that adenosine treatment results in cellular senescence in A549 lung cancer cells both in vitro and in vivo; adenosine induces cell cycle arrest and senescence in a p53/p21 dependent manner; adenosine elevates the level of phosphor-γH2AX, pCHK2 and pBRCA1, the markers for prolonged DNA damage response which are likely responsible for initiating the cellular senescence. Our study first demonstrates that adenosine suppresses growth of cancer cells by inducing senescence and provides additional evidence that adenosine could act as an effective anticancer agent for targeted cancer therapy.",

author = "Dongqin Yang and Junyao Song and Lijun Wu and Yunfang Ma and Chunhua Song and Sinisa Dovat and Tomoyuki Nishizaki and Jie Liu",

note = "Funding Information: This work is supported by the Shanghai Committee of Science and Technology of China to Jie Liu (Grant No.12JC1402000 and 12410705300); also supported partially by Four diamond foundation of Pennsylvania State University, USA, to Chunhua Song and Sinisa Dovat. We thank Sadie Hogan and Marie S. Bulathsinghala for their proof reading for English grammar. ",

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T1 - Induction of senescence by adenosine suppressing the growth of lung cancer cells

AU - Yang, Dongqin

AU - Song, Junyao

AU - Wu, Lijun

AU - Ma, Yunfang

AU - Song, Chunhua

AU - Dovat, Sinisa

AU - Nishizaki, Tomoyuki

AU - Liu, Jie

N1 - Funding Information: This work is supported by the Shanghai Committee of Science and Technology of China to Jie Liu (Grant No.12JC1402000 and 12410705300); also supported partially by Four diamond foundation of Pennsylvania State University, USA, to Chunhua Song and Sinisa Dovat. We thank Sadie Hogan and Marie S. Bulathsinghala for their proof reading for English grammar.

PY - 2013/10/11

Y1 - 2013/10/11

N2 - Extracellular adenosine is well reported to suppress tumor growth by induction of apoptosis. However, in this study we found that adenosine treatment results in cellular senescence in A549 lung cancer cells both in vitro and in vivo; adenosine induces cell cycle arrest and senescence in a p53/p21 dependent manner; adenosine elevates the level of phosphor-γH2AX, pCHK2 and pBRCA1, the markers for prolonged DNA damage response which are likely responsible for initiating the cellular senescence. Our study first demonstrates that adenosine suppresses growth of cancer cells by inducing senescence and provides additional evidence that adenosine could act as an effective anticancer agent for targeted cancer therapy.

AB - Extracellular adenosine is well reported to suppress tumor growth by induction of apoptosis. However, in this study we found that adenosine treatment results in cellular senescence in A549 lung cancer cells both in vitro and in vivo; adenosine induces cell cycle arrest and senescence in a p53/p21 dependent manner; adenosine elevates the level of phosphor-γH2AX, pCHK2 and pBRCA1, the markers for prolonged DNA damage response which are likely responsible for initiating the cellular senescence. Our study first demonstrates that adenosine suppresses growth of cancer cells by inducing senescence and provides additional evidence that adenosine could act as an effective anticancer agent for targeted cancer therapy.

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Induction of senescence by adenosine suppressing the growth of lung cancer cells

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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