Inferring protein fitness landscapes from laboratory evolution experiments

Keyphrases

• Evolution Experiment 100%
• Methylenetetrahydrofolate Reductase (MTHFR) 60%
• Protein Sequence 40%
• Protein Structure 20%
• Protein Function 20%
• Evolutionary 20%
• Modeling Approach 20%
• Evolving Populations 20%
• Fitness Landscape 20%
• Statistical Learning 20%
• Sequence of Functions 20%
• In Silico 20%
• Evolutionary Process 20%
• Epistasis 20%
• Multiple Generations 20%
• Learning Framework 20%
• Evolutionary Trajectory 20%
• Supervised Machine Learning 20%
• Sequence Structure 20%
• Unsupervised Machine Learning Approach 20%

Biochemistry, Genetics and Molecular Biology

• Dihydrofolate Reductase 100%
• Evolution 100%
• Peptide Sequence 66%
• Supervised Machine Learning 33%
• Protein Design 33%
• Unsupervised Machine Learning 33%