When approaching the management of infertility in the polycystic ovarian syndrome (PCOS) patient, there are several important considerations for maximizing favorable reproductive outcomes. Prior to conception, healthy lifestyle habits should be prioritized, with a focus on healthy body mass, optimal blood glucoses, and balanced diet and exercise regimens. Pharmacologic fertility strategies include aromatase inhibitors and selective estrogen receptor modulators (SERMs) as first-line agents. Gonadotropins can be considered when these agents fail. Alternatively, laparoscopic ovarian drilling can be utilized as a second-line approach when surgical management is indicated or desired. In vitro fertilization (IVF) is generally considered third-line unless there is an absolute indication for its use. A variant of traditional IVF known as in vitro maturation (IVM) may prove useful in this patient population to reduce the risk of ovarian hyperstimulation syndrome (OHSS). This chapter reviews the available evidence and most recent recommendations for the above treatment modalities in addition to current areas of investigation, such as the use of inositols and traditional Chinese medicine, in the care of PCOS patients desiring fertility.

Original languageEnglish (US)
Title of host publicationHandbook of Current and Novel Protocols for the Treatment of Infertility
Number of pages19
ISBN (Electronic)9780323856874
ISBN (Print)9780323901062
StatePublished - Jan 1 2023

All Science Journal Classification (ASJC) codes

  • General Agricultural and Biological Sciences
  • General Biochemistry, Genetics and Molecular Biology

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