Infertility treatment in PCOS

Since first being described in 1935 by Stein and Leventhal, polycystic ovary syndrome (PCOS) is now known to be the most common endocrinopathy in reproductive aged women with multiple medical, metabolic, and reproductive implications. PCOS is a complex heterogeneous disorder and therefore appropriate diagnosis has been debated for many years. The most widely accepted diagnostic criteria are the 2003 Rotterdam criteria, which were subsequently endorsed by the European Society for Human Reproduction and Embryology and the American Society of Reproductive Medicine. The Rotterdam Criteria based the diagnosis of PCOS by the presence of oligo/anovulation, clinical or biochemical signs of hyperandrogenism, and ultrasound evidence of polycystic morphology. Diagnosis is based on the presence of two of the three while excluding other disorders, including Cushing’s Syndrome, atypical congenital adrenal hyperplasia, androgen secreting tumors, thyroid disorders, and other disorders causing oligo/anovulation.