Inflammatory fibroid polyp of the ileocecal valve: Case report, review, and recent advances

Faye Smith-Chakmakova, Yong Jun Liu, Dipti M. Karamchandani

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


We report a case of a 72-year-old woman who underwent a right hemicolectomy for a nearobstructing mass in the ileocecal valve. The histologic diagnosis was inflammatory fibroid polyp (IFP). IFPs are rare mesenchymal lesions that can arise throughout the gastrointestinal tract. Originally considered reactive or inflammatory, recent studies report activating mutations of platelet derived growth factor receptor-alpha (PDGFRA) in IFPs, suggesting that these may in fact be neoplastic. Nonetheless, these are benign lesions cured by local excision and typically do not recur or metastasize. Our patient also had no evidence of local recurrence one year after the surgery. Hence, the clinical importance lies in distinguishing these lesions from other benign and malignant mesenchymal proliferative lesions both on a biopsy and resection specimen. We review the literature on clinicopathologic features, immunohistochemical profile, pathogenesis, recent advances, differential diagnosis, prognosis, and treatment of these uncommon lesions.

Original languageEnglish (US)
Pages (from-to)441-445
Number of pages5
JournalAnnals of clinical and laboratory science
Issue number4
StatePublished - 2015

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology
  • Molecular Biology
  • Hematology
  • Clinical Biochemistry
  • Medical Laboratory Technology


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