TY - JOUR
T1 - Influence of age on venous physiologic parameters
AU - Schina, Michael J.
AU - Neumyer, Marsha M.
AU - Healy, Dean A.
AU - Atnip, Robert G.
AU - Thiele, Brian L.
PY - 1993/11
Y1 - 1993/11
N2 - Purpose: The incidence of deep venous thrombosis increases significantly with age. Attempts to explain this association have failed to identify factors that could be contributory. We hypothesized that age-related changes in venous physiologic parameters might contribute to an increased risk of deep venous thrombosis. Methods: Air plethysmography was used to measure a number of physiologic parameters in two sets of patients. Group A consisted of 17 subjects (33 limbs), age range 23 to 40 years. Group B consisted of 11 subjects (22 limbs), age range 60 to 83 years. No subject in either group had peripheral vascular disease or a history of deep venous thrombosis. Parameters measured were venous volume, venous filling index, ejection volume, ejection fraction, residual volume fraction, and outflow fraction. Results: Venous volume and ejection fraction were significantly reduced in Group B compared with Group A. Residual volume fraction was significantly increased in Group B compared with Group A. There were no statistically significant differences in outflow fraction, venous filling index, or ejection fraction between the two groups. Conclusions: These results suggest that the efficiency of the calf muscle pump diminishes with increasing age, possibly contributing to the increased incidence of deep venous thrombosis in the elderly.
AB - Purpose: The incidence of deep venous thrombosis increases significantly with age. Attempts to explain this association have failed to identify factors that could be contributory. We hypothesized that age-related changes in venous physiologic parameters might contribute to an increased risk of deep venous thrombosis. Methods: Air plethysmography was used to measure a number of physiologic parameters in two sets of patients. Group A consisted of 17 subjects (33 limbs), age range 23 to 40 years. Group B consisted of 11 subjects (22 limbs), age range 60 to 83 years. No subject in either group had peripheral vascular disease or a history of deep venous thrombosis. Parameters measured were venous volume, venous filling index, ejection volume, ejection fraction, residual volume fraction, and outflow fraction. Results: Venous volume and ejection fraction were significantly reduced in Group B compared with Group A. Residual volume fraction was significantly increased in Group B compared with Group A. There were no statistically significant differences in outflow fraction, venous filling index, or ejection fraction between the two groups. Conclusions: These results suggest that the efficiency of the calf muscle pump diminishes with increasing age, possibly contributing to the increased incidence of deep venous thrombosis in the elderly.
UR - http://www.scopus.com/inward/record.url?scp=0027381056&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027381056&partnerID=8YFLogxK
U2 - 10.1016/0741-5214(93)90327-I
DO - 10.1016/0741-5214(93)90327-I
M3 - Article
C2 - 8230559
AN - SCOPUS:0027381056
SN - 0741-5214
VL - 18
SP - 749
EP - 752
JO - Journal of Vascular Surgery
JF - Journal of Vascular Surgery
IS - 5
ER -