Influence of cell cycle phase-specific agents on simian fetal hemoglobin synthesis

N. L. Letvin; D. C. Linch; G. P. Beardsley; K. W. McIntyre; B. A. Miller; D. G. Nathan

doi:10.1172/JCI111918

Influence of cell cycle phase-specific agents on simian fetal hemoglobin synthesis

N. L. Letvin, D. C. Linch, G. P. Beardsley, K. W. McIntyre, B. A. Miller, D. G. Nathan

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25 Scopus citations

Abstract

The results establish several important features of the fetal hemoglobin response to cytotoxic agents in the primate model. The response requires accelerated erythropoiesis and is preceded by transient reticulocytopenia. The response is produced by S phase- and M phase-specific agents when given in sufficient doses and at appropriate schedules. Passage of erythrocyte progenitors through M phase appears to be necessary for expression of the effect produced by S phase agents. The fetal hemoglobin reponse induced by cytotoxic drug administration occurs during the recovery of erythropoiesis following marrow suppression.

Original language	English (US)
Pages (from-to)	1999-2005
Number of pages	7
Journal	Journal of Clinical Investigation
Volume	75
Issue number	6
DOIs	https://doi.org/10.1172/JCI111918
State	Published - 1985

All Science Journal Classification (ASJC) codes

General Medicine

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10.1172/JCI111918

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title = "Influence of cell cycle phase-specific agents on simian fetal hemoglobin synthesis",

abstract = "The results establish several important features of the fetal hemoglobin response to cytotoxic agents in the primate model. The response requires accelerated erythropoiesis and is preceded by transient reticulocytopenia. The response is produced by S phase- and M phase-specific agents when given in sufficient doses and at appropriate schedules. Passage of erythrocyte progenitors through M phase appears to be necessary for expression of the effect produced by S phase agents. The fetal hemoglobin reponse induced by cytotoxic drug administration occurs during the recovery of erythropoiesis following marrow suppression.",

author = "Letvin, {N. L.} and Linch, {D. C.} and Beardsley, {G. P.} and McIntyre, {K. W.} and Miller, {B. A.} and Nathan, {D. G.}",

year = "1985",

doi = "10.1172/JCI111918",

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pages = "1999--2005",

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T1 - Influence of cell cycle phase-specific agents on simian fetal hemoglobin synthesis

AU - Letvin, N. L.

AU - Linch, D. C.

AU - Beardsley, G. P.

AU - McIntyre, K. W.

AU - Miller, B. A.

AU - Nathan, D. G.

PY - 1985

Y1 - 1985

N2 - The results establish several important features of the fetal hemoglobin response to cytotoxic agents in the primate model. The response requires accelerated erythropoiesis and is preceded by transient reticulocytopenia. The response is produced by S phase- and M phase-specific agents when given in sufficient doses and at appropriate schedules. Passage of erythrocyte progenitors through M phase appears to be necessary for expression of the effect produced by S phase agents. The fetal hemoglobin reponse induced by cytotoxic drug administration occurs during the recovery of erythropoiesis following marrow suppression.

AB - The results establish several important features of the fetal hemoglobin response to cytotoxic agents in the primate model. The response requires accelerated erythropoiesis and is preceded by transient reticulocytopenia. The response is produced by S phase- and M phase-specific agents when given in sufficient doses and at appropriate schedules. Passage of erythrocyte progenitors through M phase appears to be necessary for expression of the effect produced by S phase agents. The fetal hemoglobin reponse induced by cytotoxic drug administration occurs during the recovery of erythropoiesis following marrow suppression.

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VL - 75

SP - 1999

EP - 2005

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

IS - 6

ER -

Influence of cell cycle phase-specific agents on simian fetal hemoglobin synthesis

Abstract

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