Influence of cell cycle phase-specific agents on simian fetal hemoglobin synthesis

N. L. Letvin, D. C. Linch, G. P. Beardsley, K. W. McIntyre, B. A. Miller, D. G. Nathan

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


The results establish several important features of the fetal hemoglobin response to cytotoxic agents in the primate model. The response requires accelerated erythropoiesis and is preceded by transient reticulocytopenia. The response is produced by S phase- and M phase-specific agents when given in sufficient doses and at appropriate schedules. Passage of erythrocyte progenitors through M phase appears to be necessary for expression of the effect produced by S phase agents. The fetal hemoglobin reponse induced by cytotoxic drug administration occurs during the recovery of erythropoiesis following marrow suppression.

Original languageEnglish (US)
Pages (from-to)1999-2005
Number of pages7
JournalJournal of Clinical Investigation
Issue number6
StatePublished - 1985

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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