TY - JOUR
T1 - Influenza C and D viral load in cattle correlates with bovine respiratory disease (BRD)
T2 - Emerging role of orthomyxoviruses in the pathogenesis of BRD
AU - Nissly, Ruth H.
AU - Zaman, Noriza
AU - Ibrahim, Puteri Ainaa S.
AU - McDaniel, Kaitlin
AU - Lim, Levina
AU - Kiser, Jennifer N.
AU - Bird, Ian
AU - Chothe, Shubhada K.
AU - Bhushan, Gitanjali L.
AU - Vandegrift, Kurt
AU - Neibergs, Holly L.
AU - Kuchipudi, Suresh V.
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/12
Y1 - 2020/12
N2 - Bovine respiratory disease (BRD) is the costliest disease affecting the cattle industry globally. Orthomyxoviruses, influenza C virus (ICV) and influenza D virus (IDV) have recently been implicated to play a role in BRD. However, there are contradicting reports about the association of IDV and ICV to BRD. Using the largest cohort study (cattle, n = 599) to date we investigated the association of influenza viruses in cattle with BRD. Cattle were scored for respiratory symptoms and pooled nasal and pharyngeal swabs were tested for bovine viral diarrhea virus, bovine herpesvirus 1, bovine respiratory syncytial virus, bovine coronavirus, ICV and IDV by real-time PCR. Cattle that have higher viral loads of IDV and ICV also have greater numbers of co-infecting viruses than controls. More strikingly, 2 logs higher IDV viral RNA in BRD-symptomatic cattle that are co-infected animals than those infected with IDV alone. Our results strongly suggest that ICV and IDV may be significant contributors to BRD.
AB - Bovine respiratory disease (BRD) is the costliest disease affecting the cattle industry globally. Orthomyxoviruses, influenza C virus (ICV) and influenza D virus (IDV) have recently been implicated to play a role in BRD. However, there are contradicting reports about the association of IDV and ICV to BRD. Using the largest cohort study (cattle, n = 599) to date we investigated the association of influenza viruses in cattle with BRD. Cattle were scored for respiratory symptoms and pooled nasal and pharyngeal swabs were tested for bovine viral diarrhea virus, bovine herpesvirus 1, bovine respiratory syncytial virus, bovine coronavirus, ICV and IDV by real-time PCR. Cattle that have higher viral loads of IDV and ICV also have greater numbers of co-infecting viruses than controls. More strikingly, 2 logs higher IDV viral RNA in BRD-symptomatic cattle that are co-infected animals than those infected with IDV alone. Our results strongly suggest that ICV and IDV may be significant contributors to BRD.
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U2 - 10.1016/j.virol.2020.08.014
DO - 10.1016/j.virol.2020.08.014
M3 - Article
C2 - 33010670
AN - SCOPUS:85091768464
SN - 0042-6822
VL - 551
SP - 10
EP - 15
JO - Virology
JF - Virology
ER -