Inheritance of somatic mutations by animal offspring

Kate L. Vasquez Kuntz, Sheila A. Kitchen, Trinity L. Conn, Samuel A. Vohsen, Andrea N. Chan, Mark J.A. Vermeij, Christopher Page, Kristen L. Marhaver, Iliana B. Baums

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Since 1892, it has been widely assumed that somatic mutations are evolutionarily irrelevant in animals because they cannot be inherited by offspring. However, some nonbilaterians segregate the soma and germline late in development or never, leaving the evolutionary fate of their somatic mutations unknown. By investigating uni- and biparental reproduction in the coral Acropora palmata (Cnidaria, Anthozoa), we found that uniparental, meiotic offspring harbored 50% of the 268 somatic mutations present in their parent. Thus, somatic mutations accumulated in adult coral animals, entered the germline, and were passed on to swimming larvae that grew into healthy juvenile corals. In this way, somatic mutations can increase allelic diversity and facilitate adaptation across habitats and generations in animals.

Original languageEnglish (US)
Article numbereabn0707
JournalScience Advances
Volume8
Issue number35
DOIs
StatePublished - Sep 2022

All Science Journal Classification (ASJC) codes

  • General

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