Inherited uterine inadequacy: An alternate explanation for a portion of cases of defect

Frank Martin Ahern, Ronald C. Johnson

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


A substantial amount of mental retardation runs in family lines and cannot be attributed to the action of single gene pairs or to chromosomal aberrations. It was hypothesized that one of the causes of this kind of retardation might be an inherited tendency, on the part of females in the family lines, to produce an inadequate uterine environment and hence produce a high proportion of retarded offspring. If so, one would expect sisters and aunts, as compared with brothers and uncles, of retarded propositus cases to produce a higher proportion of retarded (as well as spontaneously aborted, stillborn, or neonatal casualty) offspring. An analysis of data from Reed and Reed, Mental Retardation: A Family Study, supports the hypothesis. Implications of this finding are discussed.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalBehavior Genetics
Issue number1
StatePublished - Mar 1 1973

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Genetics(clinical)


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