Inhibition is associated with metabolic syndrome and depression through inflammation

Kyle W. Murdock, Angie S. LeRoy, Christopher P. Fagundes

Research output: Contribution to journalArticlepeer-review


Inhibition is the ability to stop one's self from responding, or paying attention, to tempting/distracting stimuli or thoughts. Those with poor inhibition are at greater risk of depression and a variety of diseases of older adulthood than those with better inhibition. Inflammation may be a mechanism underlying these links. A total of 840 participants from the Midlife in the United States study completed a neuropsychological measure of inhibition, a self-report measure of depressive symptoms, and a blood draw. Results indicated that poor inhibition was associated with high interleukin-6 (IL-6). Inhibition was indirectly associated with metabolic syndrome incidence and depressive symptoms through IL-6. Findings suggest that IL-6 may be a mechanism linking inhibition with metabolic syndrome and depression.

Original languageEnglish (US)
Pages (from-to)457-461
Number of pages5
JournalStress and Health
Issue number3
StatePublished - Aug 2018

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Applied Psychology
  • Psychiatry and Mental health


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