Inhibition of Angiogenesis by Antioxidant Micelles

Masaki Moriyama; Stéphanie Metzger; André J. van der Vlies; Hiroshi Uyama; Martin Ehrbar; Urara Hasegawa

doi:10.1002/adhm.201400249

Inhibition of Angiogenesis by Antioxidant Micelles

Masaki Moriyama, Stéphanie Metzger, André J. van der Vlies, Hiroshi Uyama, Martin Ehrbar, Urara Hasegawa

Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Antioxidant micelles capable of scavenging reactive oxygen species (ROS) are prepared from poly(ethylene glycol)-b-poly(dopamine) block copolymers. The micelles inhibit tube formation of human umbilical vein endothelial cells (HUVECs) by scavenging endogenous ROS. Furthermore, the micelles inhibit angiogenesis in the chicken ex ovo chorioallantoic membrane assay. The results show that antioxidant micelles containing catechol moieties may be useful in anti-angiogenic therapy to treat various diseases such as cancer. Antioxidant micelles having catechol moieties in the core efficiently inhibit angiogenesis by scavenging reactive oxygen species as shown in the human umbilical vein endothelial cells (HUVECs) tube formation and ex ovo chicken chorioallantoic membrane (CAM) assay. These micelles may be useful in anti-angiogenic therapy to treat various diseases such as cancer.

Original language	English (US)
Pages (from-to)	569-575
Number of pages	7
Journal	Advanced Healthcare Materials
Volume	4
Issue number	4
DOIs	https://doi.org/10.1002/adhm.201400249
State	Published - Mar 1 2015

All Science Journal Classification (ASJC) codes

Biomaterials
Biomedical Engineering
Pharmaceutical Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/adhm.201400249

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title = "Inhibition of Angiogenesis by Antioxidant Micelles",

abstract = "Antioxidant micelles capable of scavenging reactive oxygen species (ROS) are prepared from poly(ethylene glycol)-b-poly(dopamine) block copolymers. The micelles inhibit tube formation of human umbilical vein endothelial cells (HUVECs) by scavenging endogenous ROS. Furthermore, the micelles inhibit angiogenesis in the chicken ex ovo chorioallantoic membrane assay. The results show that antioxidant micelles containing catechol moieties may be useful in anti-angiogenic therapy to treat various diseases such as cancer. Antioxidant micelles having catechol moieties in the core efficiently inhibit angiogenesis by scavenging reactive oxygen species as shown in the human umbilical vein endothelial cells (HUVECs) tube formation and ex ovo chicken chorioallantoic membrane (CAM) assay. These micelles may be useful in anti-angiogenic therapy to treat various diseases such as cancer.",

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AU - van der Vlies, André J.

AU - Uyama, Hiroshi

AU - Ehrbar, Martin

AU - Hasegawa, Urara

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Inhibition of Angiogenesis by Antioxidant Micelles

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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