Inhibition of herpes simplex virus reactivation by dipyridamole

R. B. Tenser; A. Gaydos; K. A. Hay

doi:10.1128/AAC.45.12.3657-3659.2001

Inhibition of herpes simplex virus reactivation by dipyridamole

R. B. Tenser, A. Gaydos, K. A. Hay

Department of Medicine

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

Herpes simplex virus (HSV) reactivation from latency was investigated. Reactivation of thymidine kinasenegative HSV, which is defective for reactivation, was greatly enhanced by thymidine (TdR). The reactivationenhancing effect of TdR was blocked by dipyridamole (DPM), a known nucleoside transport inhibitor. DPM also inhibited wild-type HSV reactivation, suggesting potential antiviral use.

Original language	English (US)
Pages (from-to)	3657-3659
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	45
Issue number	12
DOIs	https://doi.org/10.1128/AAC.45.12.3657-3659.2001
State	Published - 2001

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.45.12.3657-3659.2001

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abstract = "Herpes simplex virus (HSV) reactivation from latency was investigated. Reactivation of thymidine kinasenegative HSV, which is defective for reactivation, was greatly enhanced by thymidine (TdR). The reactivationenhancing effect of TdR was blocked by dipyridamole (DPM), a known nucleoside transport inhibitor. DPM also inhibited wild-type HSV reactivation, suggesting potential antiviral use.",

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AB - Herpes simplex virus (HSV) reactivation from latency was investigated. Reactivation of thymidine kinasenegative HSV, which is defective for reactivation, was greatly enhanced by thymidine (TdR). The reactivationenhancing effect of TdR was blocked by dipyridamole (DPM), a known nucleoside transport inhibitor. DPM also inhibited wild-type HSV reactivation, suggesting potential antiviral use.

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Inhibition of herpes simplex virus reactivation by dipyridamole

Abstract

All Science Journal Classification (ASJC) codes

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