Abstract
Herpes simplex virus (HSV) reactivation from latency was investigated. Reactivation of thymidine kinasenegative HSV, which is defective for reactivation, was greatly enhanced by thymidine (TdR). The reactivationenhancing effect of TdR was blocked by dipyridamole (DPM), a known nucleoside transport inhibitor. DPM also inhibited wild-type HSV reactivation, suggesting potential antiviral use.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3657-3659 |
| Number of pages | 3 |
| Journal | Antimicrobial agents and chemotherapy |
| Volume | 45 |
| Issue number | 12 |
| DOIs | |
| State | Published - 2001 |
All Science Journal Classification (ASJC) codes
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases
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