TY - JOUR
T1 - Inhibition of soybean and potato lipoxygenases by Bhilawanols from Bhilawan (Semecarpus anacardium) nut shell liquid and some synthetic salicylic acid analogues
AU - Nagabhushana, Kyatanahalli S.
AU - Umamaheshwari, S.
AU - Tocoli, Felismino E.
AU - Prabhu, Sandeep K.
AU - Green, Ivan R.
AU - Ramadoss, Candadai S.
N1 - Funding Information:
The work was done at the Laboratories of Vittal Mallya Scientific Research Foundation, K.R. Road, Bangalore-560 004, India and the Department of Chemistry, University of the Western Cape. We are thankful to Prof. V. P. K Nambiar for the samples, Dr P.R. Krishnaswamy and Prof. P.V. Subba Rao for their encouragement and support. KSN would like to thank Dr. B. Ravindranath and along with SKP wish to thank CSIR, India, for the Senior Research Fellowship.
PY - 2002/8
Y1 - 2002/8
N2 - Bhilawanol diene (3) isolated from bhilawan nut shell liquid was found to be a potent inhibitor of both soybean and potato lipoxygenases with IC50 values of 0.85 μM and 1.1 μM, respectively. However, the monoene (2) and saturated (1) bhilawanols exhibited relatively lower inhibitory activity. In addition, inhibition studies with synthetic analogues of salicylic acid (4-8) suggested that the unsaturated lipophilic side chain may be an absolute requirement for inhibitory activity.
AB - Bhilawanol diene (3) isolated from bhilawan nut shell liquid was found to be a potent inhibitor of both soybean and potato lipoxygenases with IC50 values of 0.85 μM and 1.1 μM, respectively. However, the monoene (2) and saturated (1) bhilawanols exhibited relatively lower inhibitory activity. In addition, inhibition studies with synthetic analogues of salicylic acid (4-8) suggested that the unsaturated lipophilic side chain may be an absolute requirement for inhibitory activity.
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U2 - 10.1080/1475636021000006243
DO - 10.1080/1475636021000006243
M3 - Article
C2 - 12530478
AN - SCOPUS:0036700416
SN - 1475-6366
VL - 17
SP - 255
EP - 259
JO - Journal of Enzyme Inhibition and Medicinal Chemistry
JF - Journal of Enzyme Inhibition and Medicinal Chemistry
IS - 4
ER -