TY - JOUR
T1 - Inhibition of the alkylation of nucleic acids and of the metabolism of 1,2-dimethylhydrazine by aminoacetonitrile
AU - Pegg, Anthony
N1 - Funding Information:
I thank Mr. James Bew for technical assistance. This research was supported by grants CA18137 and 1P30 CA18450 from NCI, DHEW.
PY - 1978/11
Y1 - 1978/11
N2 - Pretreatment of rats with aminoacetonitrile inhibited the metabolism of [14C]1,2-dimethylhydrazine to 14CO2 and increased the expiration of [14C]-azomethane. Alkylation of nucleic acids following administration of 1,2-dimethylhydrazine was reduced by aminoacetonitrile to 5% of control levels in liver, 11% of control levels in kidney and 43% of control levels in colon.
AB - Pretreatment of rats with aminoacetonitrile inhibited the metabolism of [14C]1,2-dimethylhydrazine to 14CO2 and increased the expiration of [14C]-azomethane. Alkylation of nucleic acids following administration of 1,2-dimethylhydrazine was reduced by aminoacetonitrile to 5% of control levels in liver, 11% of control levels in kidney and 43% of control levels in colon.
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U2 - 10.1016/0009-2797(78)90014-5
DO - 10.1016/0009-2797(78)90014-5
M3 - Article
C2 - 709691
AN - SCOPUS:0018145760
SN - 0009-2797
VL - 23
SP - 273
EP - 279
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
IS - 2
ER -