Inhibition of tryptophan hydroxylase activity and decreased 5-HT_1A receptor binding in a mouse model of Huntington's disease

Keyphrases

• Receptor Binding 100%
• Mouse Model 100%
• Tryptophan Hydroxylase 100%
• 5-HT1A Receptor 100%
• Huntington's Disease 100%
• Huntingtin 40%
• Brainstem 20%
• Polyglutamine 20%
• In Vitro Binding 10%
• Protein Level 10%
• Functional Consequences 10%
• Aged Mice 10%
• Enzyme Activity 10%
• Glutathione S-transferase 10%
• Serotonin 5-HT 10%
• 5-hydroxytryptamine 10%
• New Targets 10%
• Exon 1 10%
• Binding Analysis 10%
• Pharmacotherapy 10%
• Pathogenic Mechanism 10%
• Cortical Regions 10%
• Transgenic Mouse Model 10%
• Neurochemicals 10%
• Enzymatic Activity 10%
• Serotonergic System 10%
• Parahippocampal Region 10%
• Rate-limiting Enzyme 10%
• Behavioral Symptoms 10%
• 5-hydroxyindoleacetic Acid (5-HIAA) 10%
• R6/2 Transgenic Mice 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Tryptophan Hydroxylase 100%
• Huntington Chorea 100%
• Huntingtin 40%
• Polyglutamine 20%
• 5 Hydroxyindoleacetic Acid 10%

Neuroscience

• Huntington's Disease 100%
• 5-HT1A Receptor 100%
• Huntingtin 40%
• Polyglutamine 20%
• 5-Hydroxyindoleacetic Acid 10%