Initial clinical experience with the symphony heart assist system

Renzo Cecere, Robert D. Dowling, Nadia Giannetti

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Purpose Current cardiac assist devices provide full support, require a major operation, and function asynchronously to the native heart. In contrast, we developed a novel circulatory support device that provides synchronous partial support and can be placed with a minor operation. We report the first clinical implantation with the Symphony device (Abiomed, Danvers, MA). Description Patients with advanced heart failure despite optimal therapy who had exhausted all options were evaluated. A 64-year-old man with ischemic cardiomyopathy underwent implantation of the Symphony device in the right infraclavicular fossa. Evaluation After initiating device support, the cardiac index increased from 1.7 to 2.5 L/min/m2, pulmonary capillary wedge pressure decreased from 26 to 13 mm Hg, right atrial pressure decreased from 12 to 7 mm Hg, creatinine level decreased from 2.3 to 1.5 mg/dL, and New York Heart Association (NYHA) class improved from IIIB to II. Conclusions Placement of the Symphony device resulted in improvements in hemodynamics and functional status. Further clinical data will help define the role for this approach of partial synchronous support through a less invasive operation in patients with advanced heart failure.

Original languageEnglish (US)
Pages (from-to)298-301
Number of pages4
JournalAnnals of Thoracic Surgery
Issue number1
StatePublished - Jan 1 2015

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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