Injury mechanisms in acute intracerebral hemorrhage

D. Andrew Wilkinson; Aditya S. Pandey; B. Gregory Thompson; Richard F. Keep; Ya Hua; Guohua Xi

doi:10.1016/j.neuropharm.2017.09.033

Injury mechanisms in acute intracerebral hemorrhage

D. Andrew Wilkinson, Aditya S. Pandey, B. Gregory Thompson, Richard F. Keep, Ya Hua, Guohua Xi

Department of Neurosurgery

Research output: Contribution to journal › Review article › peer-review

189 Scopus citations

Abstract

Intracerebral hemorrhage (ICH) is the most common hemorrhagic stroke subtype, and rates are increasing with an aging population. Despite an increase in research and trials of therapies for ICH, mortality remains high and no interventional therapy has been demonstrated to improve outcomes. We review known mechanisms of injury, recent clinical trial results, and newly discovered signaling pathways involved in hematoma clearance. Enthusiasm remains high for methods of minimally invasive clot removal as well as pharmacologic strategies to improve recovery after ICH, both of which are currently being evaluated in clinical trials. This article is part of the Special Issue entitled ‘Cerebral Ischemia’.

Original language	English (US)
Pages (from-to)	240-248
Number of pages	9
Journal	Neuropharmacology
Volume	134
DOIs	https://doi.org/10.1016/j.neuropharm.2017.09.033
State	Published - May 15 2018

All Science Journal Classification (ASJC) codes

Pharmacology
Cellular and Molecular Neuroscience

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10.1016/j.neuropharm.2017.09.033

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title = "Injury mechanisms in acute intracerebral hemorrhage",

abstract = "Intracerebral hemorrhage (ICH) is the most common hemorrhagic stroke subtype, and rates are increasing with an aging population. Despite an increase in research and trials of therapies for ICH, mortality remains high and no interventional therapy has been demonstrated to improve outcomes. We review known mechanisms of injury, recent clinical trial results, and newly discovered signaling pathways involved in hematoma clearance. Enthusiasm remains high for methods of minimally invasive clot removal as well as pharmacologic strategies to improve recovery after ICH, both of which are currently being evaluated in clinical trials. This article is part of the Special Issue entitled {\textquoteleft}Cerebral Ischemia{\textquoteright}.",

author = "Wilkinson, {D. Andrew} and Pandey, {Aditya S.} and Thompson, {B. Gregory} and Keep, {Richard F.} and Ya Hua and Guohua Xi",

note = "Funding Information: This study was supported by grants NS-007222 , NS-073959 , NS-079157 , NS-090925 , NS-091545 , NS-093399 and NS-096917 from the National Institutes of Health (NIH) . The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

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doi = "10.1016/j.neuropharm.2017.09.033",

language = "English (US)",

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T1 - Injury mechanisms in acute intracerebral hemorrhage

AU - Wilkinson, D. Andrew

AU - Pandey, Aditya S.

AU - Thompson, B. Gregory

AU - Keep, Richard F.

AU - Hua, Ya

AU - Xi, Guohua

N1 - Funding Information: This study was supported by grants NS-007222 , NS-073959 , NS-079157 , NS-090925 , NS-091545 , NS-093399 and NS-096917 from the National Institutes of Health (NIH) . The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Publisher Copyright: © 2017 Elsevier Ltd

PY - 2018/5/15

Y1 - 2018/5/15

N2 - Intracerebral hemorrhage (ICH) is the most common hemorrhagic stroke subtype, and rates are increasing with an aging population. Despite an increase in research and trials of therapies for ICH, mortality remains high and no interventional therapy has been demonstrated to improve outcomes. We review known mechanisms of injury, recent clinical trial results, and newly discovered signaling pathways involved in hematoma clearance. Enthusiasm remains high for methods of minimally invasive clot removal as well as pharmacologic strategies to improve recovery after ICH, both of which are currently being evaluated in clinical trials. This article is part of the Special Issue entitled ‘Cerebral Ischemia’.

AB - Intracerebral hemorrhage (ICH) is the most common hemorrhagic stroke subtype, and rates are increasing with an aging population. Despite an increase in research and trials of therapies for ICH, mortality remains high and no interventional therapy has been demonstrated to improve outcomes. We review known mechanisms of injury, recent clinical trial results, and newly discovered signaling pathways involved in hematoma clearance. Enthusiasm remains high for methods of minimally invasive clot removal as well as pharmacologic strategies to improve recovery after ICH, both of which are currently being evaluated in clinical trials. This article is part of the Special Issue entitled ‘Cerebral Ischemia’.

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VL - 134

SP - 240

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JO - Neuropharmacology

JF - Neuropharmacology

ER -

Injury mechanisms in acute intracerebral hemorrhage

Abstract

All Science Journal Classification (ASJC) codes

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