Insights into the role of zinc(II) sites in hydrolytic enzymes: Study of the ZnII/X/(py)2CO (X = Cl-, N3                      -, SO4                      2-; (py)2CO=di-2-pyridyl ketone) reaction systems

Eugenia Katsoulakou; Nikolia Lalioti; Catherine P. Raptopoulou; Aris Terzis; Evy Manessi-Zoupa; Spyros P. Perlepes

doi:10.1016/S1387-7003(02)00542-7

Insights into the role of zinc(II) sites in hydrolytic enzymes: Study of the Zn^II/X/(py)₂CO (X = Cl^-, N₃ ^-, SO₄ ^2-; (py)₂CO=di-2-pyridyl ketone) reaction systems

Eugenia Katsoulakou, Nikolia Lalioti, Catherine P. Raptopoulou, Aris Terzis, Evy Manessi-Zoupa, Spyros P. Perlepes

Research output: Contribution to journal › Article › peer-review

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Abstract

A bioinorganic model approach for the investigation of substrate activation by zinc active sites in hydrolytic enzymes has been initiated. Several reaction schemes involving the substrate analogue di-2-pyridyl ketone, (py)₂CO, and Zn(II) sources afforded the new complexes [ZnCl₂{(py)₂CO}](1), [ZnCl₂{(py)₂C(OMe)(OH)}](2), [Zn₂Cl₂{(py)₂C(OMe)O}₂](3), [Zn₂(N₃)₂{(py)₂C(OMe) O}₂](4) and [Zn₂(SO₄)₂{(py)₂C(OMe) (OH)}₂(MeOH)₂](5), which have been characterized by single-crystal X-ray crystallography and spectroscopic techniques. The chemical and structural identity of the products depends on the solvent, the hydroxide concentration and the nature of the inorganic anion. The biological relevance of the prepared complexes is also discussed.

Original language	English (US)
Pages (from-to)	719-723
Number of pages	5
Journal	Inorganic Chemistry Communications
Volume	5
Issue number	9
DOIs	https://doi.org/10.1016/S1387-7003(02)00542-7
State	Published - Sep 1 2002

All Science Journal Classification (ASJC) codes

Physical and Theoretical Chemistry
Inorganic Chemistry
Materials Chemistry

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10.1016/S1387-7003(02)00542-7

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Katsoulakou, E., Lalioti, N., Raptopoulou, C. P., Terzis, A., Manessi-Zoupa, E., & Perlepes, S. P. (2002). Insights into the role of zinc(II) sites in hydrolytic enzymes: Study of the Zn^II/X/(py)₂CO (X = Cl^-, N₃ ^-, SO₄ ^2-; (py)₂CO=di-2-pyridyl ketone) reaction systems. Inorganic Chemistry Communications, 5(9), 719-723. https://doi.org/10.1016/S1387-7003(02)00542-7

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title = "Insights into the role of zinc(II) sites in hydrolytic enzymes: Study of the ZnII/X/(py)2CO (X = Cl-, N3 -, SO4 2-; (py)2CO=di-2-pyridyl ketone) reaction systems",

abstract = "A bioinorganic model approach for the investigation of substrate activation by zinc active sites in hydrolytic enzymes has been initiated. Several reaction schemes involving the substrate analogue di-2-pyridyl ketone, (py)2CO, and Zn(II) sources afforded the new complexes [ZnCl2{(py)2CO}](1), [ZnCl2{(py)2C(OMe)(OH)}](2), [Zn2Cl2{(py)2C(OMe)O}2](3), [Zn2(N3)2{(py)2C(OMe) O}2](4) and [Zn2(SO4)2{(py)2C(OMe) (OH)}2(MeOH)2](5), which have been characterized by single-crystal X-ray crystallography and spectroscopic techniques. The chemical and structural identity of the products depends on the solvent, the hydroxide concentration and the nature of the inorganic anion. The biological relevance of the prepared complexes is also discussed.",

author = "Eugenia Katsoulakou and Nikolia Lalioti and Raptopoulou, {Catherine P.} and Aris Terzis and Evy Manessi-Zoupa and Perlepes, {Spyros P.}",

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Katsoulakou, E, Lalioti, N, Raptopoulou, CP, Terzis, A, Manessi-Zoupa, E & Perlepes, SP 2002, 'Insights into the role of zinc(II) sites in hydrolytic enzymes: Study of the Zn^II/X/(py)₂CO (X = Cl^-, N₃ ^-, SO₄ ^2-; (py)₂CO=di-2-pyridyl ketone) reaction systems', Inorganic Chemistry Communications, vol. 5, no. 9, pp. 719-723. https://doi.org/10.1016/S1387-7003(02)00542-7

Insights into the role of zinc(II) sites in hydrolytic enzymes: Study of the Zn^II/X/(py)₂CO (X = Cl^-, N₃ ^-, SO₄ ^2-; (py)₂CO=di-2-pyridyl ketone) reaction systems. / Katsoulakou, Eugenia; Lalioti, Nikolia; Raptopoulou, Catherine P. et al.
In: Inorganic Chemistry Communications, Vol. 5, No. 9, 01.09.2002, p. 719-723.

Research output: Contribution to journal › Article › peer-review

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T2 - Study of the ZnII/X/(py)2CO (X = Cl-, N3 -, SO4 2-; (py)2CO=di-2-pyridyl ketone) reaction systems

AU - Katsoulakou, Eugenia

AU - Lalioti, Nikolia

AU - Raptopoulou, Catherine P.

AU - Terzis, Aris

AU - Manessi-Zoupa, Evy

AU - Perlepes, Spyros P.

PY - 2002/9/1

Y1 - 2002/9/1

N2 - A bioinorganic model approach for the investigation of substrate activation by zinc active sites in hydrolytic enzymes has been initiated. Several reaction schemes involving the substrate analogue di-2-pyridyl ketone, (py)2CO, and Zn(II) sources afforded the new complexes [ZnCl2{(py)2CO}](1), [ZnCl2{(py)2C(OMe)(OH)}](2), [Zn2Cl2{(py)2C(OMe)O}2](3), [Zn2(N3)2{(py)2C(OMe) O}2](4) and [Zn2(SO4)2{(py)2C(OMe) (OH)}2(MeOH)2](5), which have been characterized by single-crystal X-ray crystallography and spectroscopic techniques. The chemical and structural identity of the products depends on the solvent, the hydroxide concentration and the nature of the inorganic anion. The biological relevance of the prepared complexes is also discussed.

AB - A bioinorganic model approach for the investigation of substrate activation by zinc active sites in hydrolytic enzymes has been initiated. Several reaction schemes involving the substrate analogue di-2-pyridyl ketone, (py)2CO, and Zn(II) sources afforded the new complexes [ZnCl2{(py)2CO}](1), [ZnCl2{(py)2C(OMe)(OH)}](2), [Zn2Cl2{(py)2C(OMe)O}2](3), [Zn2(N3)2{(py)2C(OMe) O}2](4) and [Zn2(SO4)2{(py)2C(OMe) (OH)}2(MeOH)2](5), which have been characterized by single-crystal X-ray crystallography and spectroscopic techniques. The chemical and structural identity of the products depends on the solvent, the hydroxide concentration and the nature of the inorganic anion. The biological relevance of the prepared complexes is also discussed.

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JO - Inorganic Chemistry Communications

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Katsoulakou E, Lalioti N, Raptopoulou CP, Terzis A, Manessi-Zoupa E, Perlepes SP. Insights into the role of zinc(II) sites in hydrolytic enzymes: Study of the Zn^II/X/(py)₂CO (X = Cl^-, N₃ ^-, SO₄ ^2-; (py)₂CO=di-2-pyridyl ketone) reaction systems. Inorganic Chemistry Communications. 2002 Sep 1;5(9):719-723. doi: 10.1016/S1387-7003(02)00542-7

Insights into the role of zinc(II) sites in hydrolytic enzymes: Study of the Zn^II/X/(py)₂CO (X = Cl^-, N₃ ^-, SO₄ ^2-; (py)₂CO=di-2-pyridyl ketone) reaction systems

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