TY - JOUR
T1 - Insulin-like growth factor 1 and growth hormone binding protein in depression
T2 - A preliminary communication
AU - Franz, Bettina
AU - Buysse, Daniel J.
AU - Cherry, Christine R.
AU - Gray, Nicola S.
AU - Grochocinski, Victoria J.
AU - Frank, Ellen
AU - Kupfer, David J.
N1 - Funding Information:
Supported by National Institute of Mental Health grants MH-30915, MH-24652, MH-49115 and MH-48891, and by a grant from the Theodore and Vada Stanley Foundation. We are grateful to Dr. Judy Cameron for helpful discussions of this work.
PY - 1999/3/1
Y1 - 1999/3/1
N2 - This study was undertaken in order to advance our understanding of the distal growth hormone axis in depression. Insulin-like growth factor 1 (IGF-1) and growth hormone binding protein (GHBP) were measured in a group of 19 depressed women and a group of 16 healthy women. Using a generalized linear model, IGF-1 levels were negatively correlated with age (p = 0.0001), influenced by menstrual phase (p = 0.016), and significantly increased in the depressed group (p = 0.02). Using the same type of analysis, GHBP was significantly related to menstrual phase (p = 0.0001) and body mass index (p = 0.0001), but was not significantly different in patients and controls. IGF-1 and GHBP were positively correlated among healthy subjects (r = 0.46, p = 0.08), but not among depressed patients (r = -0.16, p = 0.51), although these correlation coefficients were not statistically significantly different from each other. These findings confirm the importance of several physiological factors in the regulation of IGF-1 and GHBP, and suggest that depression further influences this regulation.
AB - This study was undertaken in order to advance our understanding of the distal growth hormone axis in depression. Insulin-like growth factor 1 (IGF-1) and growth hormone binding protein (GHBP) were measured in a group of 19 depressed women and a group of 16 healthy women. Using a generalized linear model, IGF-1 levels were negatively correlated with age (p = 0.0001), influenced by menstrual phase (p = 0.016), and significantly increased in the depressed group (p = 0.02). Using the same type of analysis, GHBP was significantly related to menstrual phase (p = 0.0001) and body mass index (p = 0.0001), but was not significantly different in patients and controls. IGF-1 and GHBP were positively correlated among healthy subjects (r = 0.46, p = 0.08), but not among depressed patients (r = -0.16, p = 0.51), although these correlation coefficients were not statistically significantly different from each other. These findings confirm the importance of several physiological factors in the regulation of IGF-1 and GHBP, and suggest that depression further influences this regulation.
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U2 - 10.1016/S0022-3956(98)00066-1
DO - 10.1016/S0022-3956(98)00066-1
M3 - Article
C2 - 10221744
AN - SCOPUS:0032972349
SN - 0022-3956
VL - 33
SP - 121
EP - 127
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
IS - 2
ER -