Insulin-mediated modulation of cytochrome P450 gene induction profiles in primary rat hepatocyte cultures

Keyphrases

• Insulin 100%
• Hepatocyte Culture 100%
• Cytochrome P450 Enzymes 100%
• Primary Rat Hepatocytes 100%
• Gene Induction 100%
• CYP3A1 40%
• Gene Expression 20%
• MRNA Expression 20%
• Phenobarbital 20%
• CYP2B1 20%
• Phenobarbital Induction 20%
• Fold Increase 10%
• Expression Profile 10%
• Specific Genes 10%
• Dose-response Curve 10%
• Deprivation 10%
• Inducer 10%
• Albumin 10%
• Cytochrome P450 1A1 (CYP1A1) 10%
• Dose-response Relationship 10%
• Liver-specific 10%
• Magnitude Response 10%
• Bell-shaped 10%

Neuroscience

• Cytochrome P450 100%
• Gene Induction 100%
• Insulin 100%
• Phenobarbital 40%
• Cytochrome P450 3A1 40%
• Gene Expression 20%
• Cytochrome P450 2B1 20%
• Messenger RNA 20%
• Cytochrome P450 1A1 10%
• Dexamethasone 10%
• Cytochrome P450 2B2 10%
• Albumin 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Cytochrome P450 100%
• Insulin 100%
• Rat 100%
• Phenobarbital 40%
• Cytochrome P450 3A1 40%
• Cytochrome P450 2B1 20%
• Messenger RNA 20%
• Cytochrome P450 2B2 10%
• Cytochrome P450 1A1 10%
• Dexamethasone 10%
• Dose-Response Relationship 10%
• Albumin 10%