Insulin stimulates glucose transport in isolated human adipose cells through a translocation of intracellular glucose transporters to the plasma membrane: A preliminary report

E. Karnieli, B. Chernow, P. J. Hissin, I. A. Simpson, J. E. Foley

    Research output: Contribution to journalArticlepeer-review

    4 Scopus citations

    Abstract

    Insulin's effects on glucose transport activity and the subcellular distribution of glucose transporters have been examined in isolated human abdominal adipose cells, by measuring 3-O-methylglucose transport and specific D-glucose-inhibitable cytochalasin B binding to plasma membranes and low-density microsomes, respectively. Insulin appears to stimulate glucose transport in isolated human adipose cell through the translocation of glucose transporters from a large intracellular pool to the plasma membrane as initially postulated for rat adipose and muscle cells.

    Original languageEnglish (US)
    Pages (from-to)867-868
    Number of pages2
    JournalHormone and Metabolic Research
    Volume18
    Issue number12
    DOIs
    StatePublished - 1986

    All Science Journal Classification (ASJC) codes

    • Endocrinology, Diabetes and Metabolism
    • Biochemistry
    • Endocrinology
    • Clinical Biochemistry
    • Biochemistry, medical

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