TY - JOUR
T1 - Integration of biochemical and biomechanical signals regulating endothelial barrier function
AU - Sanabria, Virginia Aragon
AU - Dong, Cheng
N1 - Publisher Copyright:
Copyright © 2018 Tech Science Press
PY - 2018
Y1 - 2018
N2 - Endothelial barrier function is critical for tissue homeostasis throughout the body. Disruption of the endothelial monolayer leads to edema, vascular diseases and even cancer metastasis among other pathological conditions. Breakdown of the endothelial barrier integrity triggered by cytokines (e.g. IL-8, IL-1) and growth factors (e.g. VEGF) is well documented. However, endothelial cells are subject to major biomechanical forces that affect their behavior. Due to their unique location at the interface between circulating blood and surrounding tissues, endothelial cells experience shear stress, strain and contraction forces. More than three decades ago, it was already appreciated that shear flow caused endothelial cells alignment in the direction of the flow. After that observation, it took around 20 years to begin to uncover some of the mechanisms used by the cells for mechanotransduction. In this review, we describe mechanosensors on the endothelium identified to date and the associated signaling pathways that integrate biochemical and biomechanical inputs into biological responses and how they modulate the integrity of the endothelial barrier.
AB - Endothelial barrier function is critical for tissue homeostasis throughout the body. Disruption of the endothelial monolayer leads to edema, vascular diseases and even cancer metastasis among other pathological conditions. Breakdown of the endothelial barrier integrity triggered by cytokines (e.g. IL-8, IL-1) and growth factors (e.g. VEGF) is well documented. However, endothelial cells are subject to major biomechanical forces that affect their behavior. Due to their unique location at the interface between circulating blood and surrounding tissues, endothelial cells experience shear stress, strain and contraction forces. More than three decades ago, it was already appreciated that shear flow caused endothelial cells alignment in the direction of the flow. After that observation, it took around 20 years to begin to uncover some of the mechanisms used by the cells for mechanotransduction. In this review, we describe mechanosensors on the endothelium identified to date and the associated signaling pathways that integrate biochemical and biomechanical inputs into biological responses and how they modulate the integrity of the endothelial barrier.
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U2 - 10.3970/mcb.2018.015.001
DO - 10.3970/mcb.2018.015.001
M3 - Article
AN - SCOPUS:85044084829
SN - 1556-5297
VL - 15
SP - 1
EP - 19
JO - MCB Molecular and Cellular Biomechanics
JF - MCB Molecular and Cellular Biomechanics
IS - 1
ER -