Inter-membrane control of junctional InsP3 receptors by PIP2

Yandong Zhou; Youjun Wang; Donald L. Gill

doi:10.1016/j.tcb.2024.11.004

Inter-membrane control of junctional InsP₃ receptors by PIP₂

Yandong Zhou, Youjun Wang, Donald L. Gill

Department of Cell and Biological Systems

Research output: Contribution to journal › Short survey › peer-review

Abstract

Crosstalk between junctional membrane proteins is vital in the coordinated generation of cellular Ca²⁺ signals. New evidence (Ivanova et al.) reveals the signaling lipid, phosphatidylinositol 4,5-bisphosphate (PIP₂) reaches across plasma membrane (PM)–endoplasmic reticulum (ER) junctions to regulate inositol 1,4,5-trisphosphate receptors, controlling the critical progression of local to global Ca²⁺ signals mediating a spectrum of fundamental cellular responses.

Original language	English (US)
Pages (from-to)	1-3
Number of pages	3
Journal	Trends in Cell Biology
Volume	35
Issue number	1
DOIs	https://doi.org/10.1016/j.tcb.2024.11.004
State	Published - Jan 2025

All Science Journal Classification (ASJC) codes

Cell Biology

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10.1016/j.tcb.2024.11.004

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abstract = "Crosstalk between junctional membrane proteins is vital in the coordinated generation of cellular Ca2+ signals. New evidence (Ivanova et al.) reveals the signaling lipid, phosphatidylinositol 4,5-bisphosphate (PIP2) reaches across plasma membrane (PM)–endoplasmic reticulum (ER) junctions to regulate inositol 1,4,5-trisphosphate receptors, controlling the critical progression of local to global Ca2+ signals mediating a spectrum of fundamental cellular responses.",

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year = "2025",

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AU - Zhou, Yandong

AU - Wang, Youjun

AU - Gill, Donald L.

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AB - Crosstalk between junctional membrane proteins is vital in the coordinated generation of cellular Ca2+ signals. New evidence (Ivanova et al.) reveals the signaling lipid, phosphatidylinositol 4,5-bisphosphate (PIP2) reaches across plasma membrane (PM)–endoplasmic reticulum (ER) junctions to regulate inositol 1,4,5-trisphosphate receptors, controlling the critical progression of local to global Ca2+ signals mediating a spectrum of fundamental cellular responses.

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JO - Trends in Cell Biology

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ER -

Inter-membrane control of junctional InsP₃ receptors by PIP₂

Abstract

All Science Journal Classification (ASJC) codes

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