TY - JOUR
T1 - Interaction between cytochrome P450 gene polymorphisms and serum organochlorine TEQ levels in the risk of endometriosis
AU - Tsuchiya, Masaki
AU - Tsukino, Hiromasa
AU - Iwasaki, Motoki
AU - Sasaki, Hiroshi
AU - Tanaka, Tadao
AU - Katoh, Takahiko
AU - Patterson, Donald G.
AU - Turner, Wayman
AU - Needham, Larry
AU - Tsugane, Shoichiro
N1 - Funding Information:
We are grateful for the collaboration of Dr Amanda Sue Niskar (Israel Center for Disease Control, Gertner Institute) in designing the study protocol. We also thank Drs Tomoyuki Hanaoka (Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan) for conducting the study and his helpful comments, Hiroyuki Nakao (Department of Public Health, University of Miyazaki, Miya-zaki, Japan) for his support of the statistical analysis and Michinori Kabuto (National Institute for Environmental Studies, Ibaraki, Japan) for his helpful comments. This study was supported by Grants-in-Aid for Research on Risk of Chemical Substances, and for the Third Term Comprehensive 10-Year Strategy for Cancer Control from the Ministry of Health, Labour and Welfare of Japan. Masaki Tsuchiya and Hiromasa Tsukino are Awardees of Research Resident Fellowships from the Foundation for Promotion of Cancer Research for the Third and Second Term Comprehensive 10-Year Strategy for Cancer Control.
PY - 2007/6
Y1 - 2007/6
N2 - Exposure to dioxins and polychlorinated biphenyls (PCBs) has been suggested as a possible etiologic factor for endometriosis, but the association remains highly controversial. To assess whether cytochrome P450 (CYP) gene polymorphisms modulate the effect of dioxins and/or PCBs in endometriosis risk, we conducted a case-control study among infertile Japanese women. A total of 138 eligible women aged 20-45 were diagnosed laparoscopically and classified into three subgroups: control (no endometriosis), early endometriosis (stages I-II) and advanced endometriosis (stages III-IV). Neither CYP1A1 Ile462Val and CYP1B1 Leu432Val polymorphisms (genotypes with versus genotypes without the minor allele) nor serum dioxin and PCB toxic equivalency (TEQ) levels (low versus high) were independently associated with either early or advanced endometriosis risk. However, genotypes with the CYP1A1 462Val allele showed a statistically significant reduced risk of advanced endometriosis in combination with high serum dioxin TEQ levels (adjusted odds ratio = 0.13, 95% confidence interval: 0.02-(0.76) (P for interaction = 0.08). Although no association was found between serum PCB TEQ level and advanced endometriosis in any stratum of CYP1B1 Leu432Val polymorphism, a statistically significant interaction was found (P for interaction = 0.05). CYP1A1 and CYP1B1 polymorphisms may modify the relation between environmental exposure to organochlorine and advanced endometriosis risk.
AB - Exposure to dioxins and polychlorinated biphenyls (PCBs) has been suggested as a possible etiologic factor for endometriosis, but the association remains highly controversial. To assess whether cytochrome P450 (CYP) gene polymorphisms modulate the effect of dioxins and/or PCBs in endometriosis risk, we conducted a case-control study among infertile Japanese women. A total of 138 eligible women aged 20-45 were diagnosed laparoscopically and classified into three subgroups: control (no endometriosis), early endometriosis (stages I-II) and advanced endometriosis (stages III-IV). Neither CYP1A1 Ile462Val and CYP1B1 Leu432Val polymorphisms (genotypes with versus genotypes without the minor allele) nor serum dioxin and PCB toxic equivalency (TEQ) levels (low versus high) were independently associated with either early or advanced endometriosis risk. However, genotypes with the CYP1A1 462Val allele showed a statistically significant reduced risk of advanced endometriosis in combination with high serum dioxin TEQ levels (adjusted odds ratio = 0.13, 95% confidence interval: 0.02-(0.76) (P for interaction = 0.08). Although no association was found between serum PCB TEQ level and advanced endometriosis in any stratum of CYP1B1 Leu432Val polymorphism, a statistically significant interaction was found (P for interaction = 0.05). CYP1A1 and CYP1B1 polymorphisms may modify the relation between environmental exposure to organochlorine and advanced endometriosis risk.
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U2 - 10.1093/molehr/gam018
DO - 10.1093/molehr/gam018
M3 - Article
C2 - 17449539
AN - SCOPUS:34447523957
SN - 1360-9947
VL - 13
SP - 399
EP - 404
JO - Molecular Human Reproduction
JF - Molecular Human Reproduction
IS - 6
ER -