Interaction of responsive/switchable surfaces with cells

This chapter will explore the properties altered by switchable materials and subsequently the effect on cell behaviors. Topics will explore cell phenotypes from early adhesion through differentiation. Material behaviors considered will include, but are not limited to, altered surface chemistries (e.g. hydrophilic to hydrophobic); altered surface geometries (e.g. shape or stiffness change in response to a stimulus); and altered factor release (e.g. stimulus triggered release of a growth factor). Finally, the chapter will conclude by exploring the future of switchable materials and how they can exploit multiple cell phenotypes by responding to cell-generated stimuli (e.g. a proliferative cell population generates more tension as they reach confluence which promotes release of a growth factor driving differentiation).