Abstract
The 8-aminoquinoline tafenoquine (TFQ), a primaquine derivative, is currently in late-stage clinical development for the radical cure of P. vivax. Here drug interactions between TFQ and chloroquine and six artemisinin-combination therapy (ACT) partner drugs in P. falciparum asexual stages and gametocytes were investigated. TFQ was mostly synergistic with the ACT-partner drugs in asexual parasites regardless of genetic backgrounds. However, at fixed ratios of 1:3, 1:1 and 3:1, TFQ only interacted synergistically with naphthoquine, pyronaridine and piperaquine in gametocytes. This study indicated that TFQ and ACT-partner drugs will likely have increased potency against asexual stages of the malaria parasites, whereas some drugs may interfere with each other against the P. falciparum gametocytes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 131-137 |
| Number of pages | 7 |
| Journal | International Journal for Parasitology: Drugs and Drug Resistance |
| Volume | 7 |
| Issue number | 2 |
| DOIs | |
| State | Published - Aug 1 2017 |
All Science Journal Classification (ASJC) codes
- Parasitology
- Infectious Diseases
- Pharmacology (medical)
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