Abstract
Multiple studies have shown that the activity of alkaline phosphatase (AP) increases during Alzheimer's disease (AD). In this paper, using UV-Visible spectroscopy, we show that this increase in activity is due to its interaction with key components of AD such as amyloid β peptide and acetylcholinesterase. Activity increase also occurs due to high concentrations of acetylcholine and choline. These conditions are present in AD or could occur due to drugs used for treating AD.
Original language | English (US) |
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Pages (from-to) | 21149-21153 |
Number of pages | 5 |
Journal | Physical Chemistry Chemical Physics |
Volume | 25 |
Issue number | 32 |
DOIs | |
State | Published - Jul 28 2023 |
All Science Journal Classification (ASJC) codes
- General Physics and Astronomy
- Physical and Theoretical Chemistry