Interactions with amyloid beta peptide and acetylcholinesterase increase alkaline phosphatase activity

Ashlesha Bhide, Ayusman Sen

Research output: Contribution to journalArticlepeer-review

Abstract

Multiple studies have shown that the activity of alkaline phosphatase (AP) increases during Alzheimer's disease (AD). In this paper, using UV-Visible spectroscopy, we show that this increase in activity is due to its interaction with key components of AD such as amyloid β peptide and acetylcholinesterase. Activity increase also occurs due to high concentrations of acetylcholine and choline. These conditions are present in AD or could occur due to drugs used for treating AD.

Original languageEnglish (US)
Pages (from-to)21149-21153
Number of pages5
JournalPhysical Chemistry Chemical Physics
Volume25
Issue number32
DOIs
StatePublished - Jul 28 2023

All Science Journal Classification (ASJC) codes

  • General Physics and Astronomy
  • Physical and Theoretical Chemistry

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