Intercellular communication mediated by the extracellular calcium-sensing receptor

Aldebaran M. Hofer, Silvana Curci, Marc A. Doble, Edward M. Brown, David I. Soybel

Research output: Contribution to journalArticlepeer-review

126 Scopus citations


Agonist-evoked, intracellular Ca2+-signalling events are associated with active extrusion of Ca2+ across the plasrna membrane, implying a local increase in Ca2+ concentration ([Ca2+]) at the extracellular face of the cell. The possibility that these external [Ca2+] changes may have specific physiological functions has received little consideration in the past. Here we show that physiological ambient [Ca2+], Ca2+ mobilization in one cell produces an extracellular signal that can be detected in nearby cells expressing the extracellular Ca2+-sensing receptor (CaR), a cell-surface receptor for divalent cations wth a widespread tissue distribution. The CaR may therefore mediate a universal form of intercellular communication that allows cells to be informed of the Ca2+-signalling status of their neighbours.

Original languageEnglish (US)
Pages (from-to)392-398
Number of pages7
JournalNature Cell Biology
Issue number7
StatePublished - 2000

All Science Journal Classification (ASJC) codes

  • Cell Biology


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