TY - JOUR
T1 - Interleukin-22
T2 - A likely target for treatment of autoimmune diseases
AU - Yang, Xuyan
AU - Zheng, Song Guo
N1 - Funding Information:
This work was partly supported by the NIH (grants AR-059103 and AI-084359 ), the Rheumatology Research Foundation of the American College of Rheumatology (Within Our Reach program grant) , and the Science Foundation of Science and Technology Department of Zhejiang Province (No. 2007C3305 ).
PY - 2014/6
Y1 - 2014/6
N2 - Interleukin-22 (IL-22) is a member of IL-10 family cytokines that is produced by many different types of lymphocytes including both those of the innate and adaptive immune systems. This includes activated T cells, most notably Th17 and Th22 cells, and NK cells, γδ T cells, LTi cells and LTi-like cells. IL-22 mediates its effects via the IL-22-IL-22R complex and subsequent Janus kinase-signal transducer and activators of transcription (JAK-STAT) signaling pathway. Recently accumulated evidence has indicated that IL-22 also plays an important role in the pathogenesis of many autoimmune diseases. In this review, we discuss the recent findings and advancement of the role for IL-22 in several autoimmune diseases, such as psoriasis, rheumatoid arthritis (RA), hepatitis, graft versus host disease (GHVD) and allergic diseases, implicating that target IL-22 may have a therapeutic potential in those autoimmune diseases.
AB - Interleukin-22 (IL-22) is a member of IL-10 family cytokines that is produced by many different types of lymphocytes including both those of the innate and adaptive immune systems. This includes activated T cells, most notably Th17 and Th22 cells, and NK cells, γδ T cells, LTi cells and LTi-like cells. IL-22 mediates its effects via the IL-22-IL-22R complex and subsequent Janus kinase-signal transducer and activators of transcription (JAK-STAT) signaling pathway. Recently accumulated evidence has indicated that IL-22 also plays an important role in the pathogenesis of many autoimmune diseases. In this review, we discuss the recent findings and advancement of the role for IL-22 in several autoimmune diseases, such as psoriasis, rheumatoid arthritis (RA), hepatitis, graft versus host disease (GHVD) and allergic diseases, implicating that target IL-22 may have a therapeutic potential in those autoimmune diseases.
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U2 - 10.1016/j.autrev.2013.11.008
DO - 10.1016/j.autrev.2013.11.008
M3 - Review article
C2 - 24418299
AN - SCOPUS:84896547798
SN - 1568-9972
VL - 13
SP - 615
EP - 620
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
IS - 6
ER -
