TY - JOUR
T1 - Intestinal mesenchymal cells
AU - Pinchuk, I. V.
AU - Mifflin, R. C.
AU - Saada, J. I.
AU - Powell, D. W.
N1 - Funding Information:
Acknowledgments The research performed in the authors’ laboratories mentioned in this article was supported by grants from the National Institutes of Health, DK 55783 and CA 127229 (both to Dr. Powell), and an American Gastroenterological Association Scholars Award (Dr. Pinchuk).
PY - 2010/10
Y1 - 2010/10
N2 - The non-white blood cell mesenchymal elements of the intestinal lamina propria are the myofibroblasts, fibroblasts, pericytes, stromal stem cells, muscularis mucosae, and the smooth muscle of the villus core associated with the lymphatic lacteal. We review the functional anatomy of these mesenchymal cells, what is known about their origin in the embryo and their replacement in adults, their putative role in intestinal mucosal morphogenesis, and the intestinal stem cell niche, and we consider new information about myofibroblasts as nonprofessional immune cells. Although our knowledge of the function of mesenchymal cells in intestinal disease is rudimentary, we briefly consider here their roles in cancer and intestinal inflammation.
AB - The non-white blood cell mesenchymal elements of the intestinal lamina propria are the myofibroblasts, fibroblasts, pericytes, stromal stem cells, muscularis mucosae, and the smooth muscle of the villus core associated with the lymphatic lacteal. We review the functional anatomy of these mesenchymal cells, what is known about their origin in the embryo and their replacement in adults, their putative role in intestinal mucosal morphogenesis, and the intestinal stem cell niche, and we consider new information about myofibroblasts as nonprofessional immune cells. Although our knowledge of the function of mesenchymal cells in intestinal disease is rudimentary, we briefly consider here their roles in cancer and intestinal inflammation.
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U2 - 10.1007/s11894-010-0135-y
DO - 10.1007/s11894-010-0135-y
M3 - Review article
C2 - 20690004
AN - SCOPUS:77958166490
SN - 1522-8037
VL - 12
SP - 310
EP - 318
JO - Current gastroenterology reports
JF - Current gastroenterology reports
IS - 5
ER -