@article{3665f85004f44c50aae4b5a925468c22,
title = "Intestinal Monocyte-Derived Macrophages Control Commensal-Specific Th17 Responses",
abstract = "Generation of different CD4 T cell responses to commensal and pathogenic bacteria is crucial for maintaining a healthy gut environment, but the associated cellular mechanisms are poorly understood. Dendritic cells (DCs) and macrophages (Mfs) integrate microbial signals and direct adaptive immunity. Although the role of DCs in initiating T cell responses is well appreciated, how Mfs contribute to the generation of CD4 T cell responses to intestinal microbes is unclear. Th17 cells are critical for mucosal immune protection and at steady state are induced by commensal bacteria, such as segmented filamentous bacteria (SFB). Here, we examined the roles of mucosal DCs and Mfs in Th17 induction by SFB in vivo. We show that Mfs, and not conventional CD103+ DCs, are essential for the generation of SFB-specific Th17 responses. Thus, Mfs drive mucosal T cell responses to certain commensal bacteria.",
author = "Casandra Panea and Farkas, {Adam M.} and Yoshiyuki Goto and Shahla Abdollahi-Roodsaz and Carolyn Lee and Bal{\'a}zs Koscs{\'o} and Kavitha Gowda and Hohl, {Tobias M.} and Milena Bogunovic and Ivanov, {Ivaylo I.}",
note = "Funding Information: We thank Ingrid Leiner and Eric Pamer at the Memorial Sloan Kettering Cancer Center for providing CCR2-GFP and CCR2-DTR mice. We thank Lei Ding for expert advice in BM experiments. We thank Darya Esterhazy and Daniel Mucida at the Rockefeller University for reagents. We thank Amir Figueroa, Kristie Gordon, and Siu-Hong Ho at the Columbia Microbiology, Cancer Center, and Center for Translational Immunology Flow Cytometry Cores for cell sorting. We thank Boris Reizis and Steve Reiner for invaluable advice and scientific discussions. This work was supported by NIH R01-DK098378 to I.I.I., R01-AI093808 to T.M.H., and by the Crohn{\textquoteright}s and Colitis Foundation of America SRA#259540 to I.I.I. T.M.H. is a Burroughs Welcome Fund Investigator in the Pathogenesis of Infectious Diseases. I.I.I. is a Pew Scholar in the Biomedical Sciences, supported by the Pew Charitable Trust. Publisher Copyright: {\textcopyright} 2015 The Authors.",
year = "2015",
month = aug,
day = "25",
doi = "10.1016/j.celrep.2015.07.040",
language = "English (US)",
volume = "12",
pages = "1314--1324",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "8",
}