TY - JOUR
T1 - Intra-amygdala infusion of the protein kinase Mzeta inhibitor ZIP disrupts foreground context fear memory
AU - Kwapis, Janine L.
AU - Jarome, Timothy J.
AU - Gilmartin, Marieke R.
AU - Helmstetter, Fred J.
N1 - Funding Information:
This research was supported by the National Institutes of Mental Health (NIMH) Grant R01MH069558 to Fred J. Helmstetter and NIMH Grant F31MH090685 to Janine L. Kwapis.
PY - 2012/9
Y1 - 2012/9
N2 - Protein kinase Mzeta has been the subject of much recent interest, as it is the only molecule currently identified to maintain memory. Despite the wealth of studies investigating PKMζ in memory, questions remain about which types of memory PKMζ supports. Further, it is unclear how long the inhibitor of PKMz, ζ-pseudosubstrate inhibitory peptide (ZIP) remains in the brain after infusion. Here, we demonstrate that foreground context fear memory requires PKMζ activity in the amygdala. We also show that ZIP is fully cleared from the brain by 24. h after infusion. These data contribute to a growing body of literature that demonstrates that PKMζ plays a key role in maintaining amygdala-dependent memory and provides new information about the degradation timecourse of the most commonly used inhibitor of PKMζ, ZIP.
AB - Protein kinase Mzeta has been the subject of much recent interest, as it is the only molecule currently identified to maintain memory. Despite the wealth of studies investigating PKMζ in memory, questions remain about which types of memory PKMζ supports. Further, it is unclear how long the inhibitor of PKMz, ζ-pseudosubstrate inhibitory peptide (ZIP) remains in the brain after infusion. Here, we demonstrate that foreground context fear memory requires PKMζ activity in the amygdala. We also show that ZIP is fully cleared from the brain by 24. h after infusion. These data contribute to a growing body of literature that demonstrates that PKMζ plays a key role in maintaining amygdala-dependent memory and provides new information about the degradation timecourse of the most commonly used inhibitor of PKMζ, ZIP.
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U2 - 10.1016/j.nlm.2012.05.003
DO - 10.1016/j.nlm.2012.05.003
M3 - Article
C2 - 22659643
AN - SCOPUS:84865282197
SN - 1074-7427
VL - 98
SP - 148
EP - 153
JO - Neurobiology of Learning and Memory
JF - Neurobiology of Learning and Memory
IS - 2
ER -