Intramolecular metal catalyzed kharasch cyclizations of olefinic α-halo esters and acids

Functionalized carbocyclic compounds are produced by intramolecular Kharasch radical cyclization reactions catalyzed by various transition metal complexes. Several unsaturated mono-α-haloesters and acids can be efficiently transformed to γ-halocarboxyl and γ-lactone carbocycles via exo closure of a 5-hexenyl type radical intermediate. The cyclization methodology is useful for synthesis of both fused and bridged carbocycles.