TY - JOUR
T1 - Intraoperative Bioprinting
T2 - Repairing Tissues and Organs in a Surgical Setting
AU - Wu, Yang
AU - Ravnic, Dino J.
AU - Ozbolat, Ibrahim T.
N1 - Funding Information:
This research was funded by the Osteology Foundation (15-042, 18-076), International Team for Implantology (1275_2017), National Science Foundation (1600118), and National Institutes of Health (R01DE028614). The authors are also thankful to Advanced Solutions Inc. and Ms Talley Fisher (from Penn State) for providing Figure 2A and 2B, respectively.
Funding Information:
This research was funded by the Osteology Foundation ( 15-042 , 18-076 ), International Team for Implantology ( 1275_2017 ), National Science Foundation ( 1600118 ), and National Institutes of Health ( R01DE028614 ). The authors are also thankful to Advanced Solutions Inc. and Ms Talley Fisher (from Penn State) for providing Figure 2 A and 2 B, respectively.
Publisher Copyright:
© 2020 Elsevier Ltd
PY - 2020/6
Y1 - 2020/6
N2 - 3D bioprinting directly into injured sites in a surgical setting, intraoperative bioprinting (IOB), is an effective process, in which the defect information can be rapidly acquired and then repaired via bioprinting on a live subject. In patients needing tissue resection, debridement, traumatic reconstruction, or fracture repair, the ability to scan and bioprint immediately following surgical preparation of the defect site has great potential to improve the precision and efficiency of these procedures. In this opinion article, we provide the reader with current major limitations of IOB from engineering and clinical points of view, as well as possibilities of future translation of bioprinting technologies from bench to bedside, and expound our perspectives in the context of IOB of composite and vascularized tissues.
AB - 3D bioprinting directly into injured sites in a surgical setting, intraoperative bioprinting (IOB), is an effective process, in which the defect information can be rapidly acquired and then repaired via bioprinting on a live subject. In patients needing tissue resection, debridement, traumatic reconstruction, or fracture repair, the ability to scan and bioprint immediately following surgical preparation of the defect site has great potential to improve the precision and efficiency of these procedures. In this opinion article, we provide the reader with current major limitations of IOB from engineering and clinical points of view, as well as possibilities of future translation of bioprinting technologies from bench to bedside, and expound our perspectives in the context of IOB of composite and vascularized tissues.
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U2 - 10.1016/j.tibtech.2020.01.004
DO - 10.1016/j.tibtech.2020.01.004
M3 - Review article
C2 - 32407688
AN - SCOPUS:85079885470
SN - 0167-7799
VL - 38
SP - 594
EP - 605
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 6
ER -