TY - JOUR
T1 - Intrathoracic volume compensation chamber function in clinical left ventricular assistance
AU - Snyder, A.
AU - El-Banoyosi, A.
AU - Fey, O.
AU - Pae, Walter
AU - Rosenberg, Gerson
AU - Pierce, W.
AU - Lewis, J.
AU - Frank, D.
AU - Thompson, J.
AU - Zintak, H.
AU - Scholl, S.
PY - 2000
Y1 - 2000
N2 - Volume compensation chambers have long been proposed as a means to vent the rigid housing of an implanted ventricular assist device, in order to permit free filling and emptying of the pump while avoiding percutaneous vent lines. As part of the first clinical trials of our completely implanted, intact-skin ventricular assist system, we have assessed the function of the volume compensation chamber. The chamber is circular in cross-section, 12 cm in diameter and 1 cm thick. The chamber body is constructed of dip-cast segmented polyurethane. An interior tubing skeleton helps maintain chamber shape when implanted. A velour covering provides the necessary texture to keep the chamber flexible over the long term. A self-sealing percutaneous infusion port is used to replenish gas that leaves the chamber by diffusion into surrounding tissues. Chambers were implanted in two patients as part of the clinical trial of the overall system. Chambers were placed in the left chest between the lung and the pleura. Chamber volume was set in the perioperative period, then replenished every four weeks. A pressure monitor and non-coring needle are the only special equipment needed for the replenishment procedure. A simpler procedure, intended for use in a primary care office, is being developed. Chamber implantation was well-tolerated. There was sufficient capacity to x rays to verify chamber location, without interfering with other diagnostic needs. The infusion port was readily located, and the replenishment procedure easily completed. Early results indicate that in humans the chambers may be more compliant, and capable of operating over a wider volume range, than they are in calves. Thus, further extension of the time between gas replenishments may be possible. New materials under development may more significantly increase the time between chamber refills.
AB - Volume compensation chambers have long been proposed as a means to vent the rigid housing of an implanted ventricular assist device, in order to permit free filling and emptying of the pump while avoiding percutaneous vent lines. As part of the first clinical trials of our completely implanted, intact-skin ventricular assist system, we have assessed the function of the volume compensation chamber. The chamber is circular in cross-section, 12 cm in diameter and 1 cm thick. The chamber body is constructed of dip-cast segmented polyurethane. An interior tubing skeleton helps maintain chamber shape when implanted. A velour covering provides the necessary texture to keep the chamber flexible over the long term. A self-sealing percutaneous infusion port is used to replenish gas that leaves the chamber by diffusion into surrounding tissues. Chambers were implanted in two patients as part of the clinical trial of the overall system. Chambers were placed in the left chest between the lung and the pleura. Chamber volume was set in the perioperative period, then replenished every four weeks. A pressure monitor and non-coring needle are the only special equipment needed for the replenishment procedure. A simpler procedure, intended for use in a primary care office, is being developed. Chamber implantation was well-tolerated. There was sufficient capacity to x rays to verify chamber location, without interfering with other diagnostic needs. The infusion port was readily located, and the replenishment procedure easily completed. Early results indicate that in humans the chambers may be more compliant, and capable of operating over a wider volume range, than they are in calves. Thus, further extension of the time between gas replenishments may be possible. New materials under development may more significantly increase the time between chamber refills.
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U2 - 10.1097/00002480-200003000-00187
DO - 10.1097/00002480-200003000-00187
M3 - Conference article
AN - SCOPUS:0034158754
SN - 0042-1215
VL - 46
SP - 197
JO - Unknown Journal
JF - Unknown Journal
IS - 2
T2 - 46th Annual Conference and Exposition of ASAIO
Y2 - 28 June 2000 through 1 July 2000
ER -