Intravitreal level of pigment epithelium-derived factor (PEDF)

N. Ogata, T. Nishimura, J. Tombran-Tink, M. Matsumura

Research output: Contribution to journalArticlepeer-review


Pigment epithelium-derived factor (PEDF), a serpin-like protein, is claimed to be a neurotropic factor and a potent inhibitor of intraocular angiogenesis. We quantitated the intravitreal level of PEDF in 23 eyes that received vitreous surgery using enzyme-linked immunosorbent assay (ELISA). The series comprised proliferative diabetic retinopathy 8 eyes, rhegmatogenous retinal detachment 7 eyes, idiopathic macular hole 4 eyes and others. The concentration of PEDF averaged 0.37 ± 0.13 μg/ml in diabetic retinopathy, 3.53 ± 0.85 μg/ml in retinal detachment and 1.76 ± 0.85 μg/ml in macular hole. Its value in macular hole was similar to the normal level. Its lower levels in proliferative diabetic retinopathy seemed to show decreased inhibitory effect for intraocular angiogenesis. Its increased levels in rhegmatogenous retinal detachment seemed to show a neuroprotective role for the detached retina.

Original languageEnglish (US)
Pages (from-to)1077-1079
Number of pages3
JournalJapanese Journal of Clinical Ophthalmology
Issue number6
StatePublished - 2001

All Science Journal Classification (ASJC) codes

  • Ophthalmology


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