Intricacies in ATP-dependent clamp loading: Variations across replication systems

M. A. Trakselis, S. J. Benkovic

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


DNA replication requires the coordinated effort of many proteins to create a highly processive biomachine able to replicate entire genomes in a single process. The clamp proteins confer on replisomes this property of processivity but in turn require clamp loaders for their functional assembly onto DNA. A more detailed view of the mechanisms for holoenzyme assembly in replication systems has been obtained from the advent of novel solution experiments and the appearance of low- and high-resolution structures for the clamp loaders.

Original languageEnglish (US)
Pages (from-to)999-1004
Number of pages6
Issue number11
StatePublished - 2001

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology


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