Abstract
DNA replication requires the coordinated effort of many proteins to create a highly processive biomachine able to replicate entire genomes in a single process. The clamp proteins confer on replisomes this property of processivity but in turn require clamp loaders for their functional assembly onto DNA. A more detailed view of the mechanisms for holoenzyme assembly in replication systems has been obtained from the advent of novel solution experiments and the appearance of low- and high-resolution structures for the clamp loaders.
Original language | English (US) |
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Pages (from-to) | 999-1004 |
Number of pages | 6 |
Journal | Structure |
Volume | 9 |
Issue number | 11 |
DOIs | |
State | Published - 2001 |
All Science Journal Classification (ASJC) codes
- Structural Biology
- Molecular Biology