Invertebrate immunity and the limits of mechanistic immunology

Tom J. Little; Dan Hultmark; Andrew F. Read

doi:10.1038/ni1219

Invertebrate immunity and the limits of mechanistic immunology

Tom J. Little, Dan Hultmark, Andrew F. Read

Research output: Contribution to journal › Review article › peer-review

249 Scopus citations

Abstract

Rapid progress is being made in elucidating the molecular mechanisms involved in invertebrate immunity. This search for molecules runs the risk of missing important phenomena. In vertebrates, acquired protection and pathogen-specific responses were demonstrated experimentally long before the mechanisms responsible were elucidated. Without analogous experiments, mechanism-driven work may not demonstrate the full richness of invertebrate immunity.

Original language	English (US)
Pages (from-to)	651-654
Number of pages	4
Journal	Nature Immunology
Volume	6
Issue number	7
DOIs	https://doi.org/10.1038/ni1219
State	Published - 2005

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology

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10.1038/ni1219

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title = "Invertebrate immunity and the limits of mechanistic immunology",

abstract = "Rapid progress is being made in elucidating the molecular mechanisms involved in invertebrate immunity. This search for molecules runs the risk of missing important phenomena. In vertebrates, acquired protection and pathogen-specific responses were demonstrated experimentally long before the mechanisms responsible were elucidated. Without analogous experiments, mechanism-driven work may not demonstrate the full richness of invertebrate immunity.",

author = "Little, {Tom J.} and Dan Hultmark and Read, {Andrew F.}",

note = "Funding Information: The authors thank A. Graham, A. Hayward and L. R{\aa}berg for comments. Supported by the University of Edinburgh School of Biological Sciences, Wellcome Trust and Natural Environment Research Council (T.L.); the Swedish Research Council, Swedish Cancer Society, Swedish Foundation for Strategic Research and Wallenberg Consortium North (D.H.); and the Wellcome Trust and Biotechnology and Biological Sciences Research Council (A.R.).",

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AU - Hultmark, Dan

AU - Read, Andrew F.

N1 - Funding Information: The authors thank A. Graham, A. Hayward and L. Råberg for comments. Supported by the University of Edinburgh School of Biological Sciences, Wellcome Trust and Natural Environment Research Council (T.L.); the Swedish Research Council, Swedish Cancer Society, Swedish Foundation for Strategic Research and Wallenberg Consortium North (D.H.); and the Wellcome Trust and Biotechnology and Biological Sciences Research Council (A.R.).

PY - 2005

Y1 - 2005

N2 - Rapid progress is being made in elucidating the molecular mechanisms involved in invertebrate immunity. This search for molecules runs the risk of missing important phenomena. In vertebrates, acquired protection and pathogen-specific responses were demonstrated experimentally long before the mechanisms responsible were elucidated. Without analogous experiments, mechanism-driven work may not demonstrate the full richness of invertebrate immunity.

AB - Rapid progress is being made in elucidating the molecular mechanisms involved in invertebrate immunity. This search for molecules runs the risk of missing important phenomena. In vertebrates, acquired protection and pathogen-specific responses were demonstrated experimentally long before the mechanisms responsible were elucidated. Without analogous experiments, mechanism-driven work may not demonstrate the full richness of invertebrate immunity.

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JO - Nature Immunology

JF - Nature Immunology

IS - 7

ER -

Invertebrate immunity and the limits of mechanistic immunology

Abstract

All Science Journal Classification (ASJC) codes

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