Investigation of the role of tyrosine-114 in the activity of human O⁶- alkylguanine-DNA alkyltranferase

Keyphrases

• Tyrosine 100%
• O6-methylguanine 100%
• Escherichia Coli 50%
• Methylated DNA 50%
• Amino Acids 33%
• Oligodeoxynucleotide 33%
• DNA Substrates 33%
• N-methyl-N′-nitro-N-nitrosoguanidine 33%
• Reaction Rate 16%
• Alkylation 16%
• Highly Effective 16%
• Low Molecular Weight 16%
• Double Strand 16%
• Phenylalanine 16%
• Protective Effect 16%
• Mutant Protein 16%
• Drastic Change 16%
• Reduction Degree 16%
• Threonine 16%
• Alkylating Agents 16%
• DNA Repair Enzymes 16%
• O6-methylguanine-DNA Methyltransferase 16%
• Alkyl Group 16%
• Pseudosubstrate 16%
• Conserved Amino Acids 16%
• Methylating Agent 16%
• Glutamic Acid 16%
• Reducing Activity 16%
• Cell Killing 16%
• DNA Helix 16%

Pharmacology, Toxicology and Pharmaceutical Science

• Amino Acid 100%
• Escherichia coli 100%
• 6 O Methylguanine 100%
• Oligodeoxynucleotide 66%
• Nitrosoguanidine 66%
• 6 O Benzylguanine 66%
• Phenylalanine 33%
• Base 33%
• Glutamic Acid 33%
• Alanine 33%
• Alkyl Group 33%
• Alkylating Agent 33%
• 6 O Alkylguanine DNA Alkyltransferase 33%
• Threonine 33%
• Mutant Protein 33%

Biochemistry, Genetics and Molecular Biology

• Tyrosine 100%
• Amino Acids 75%
• Escherichia coli 75%
• Wild Type 75%
• DNA Methylation 75%
• 6-O-Methylguanine 75%
• Molecular Weight 25%
• Mutant Protein 25%
• DNA Repair Protein 25%
• DNA Helix 25%
• Threonine 25%
• Glutamic Acid 25%
• Phenylalanine 25%
• Alanine 25%
• Cell Killing 25%
• Methylating Agents 25%