Involvement of apoptosis in ovarian follicular atresia and postovulatory regression

Jonathan L. Tilly, Kim I. Kowalski, Alan L. Johnson, Aaron J.W. Hsueh

Research output: Contribution to journalArticlepeer-review

599 Scopus citations


In the ovary, greater than 99% of the follicles present at birth are destined to degenerate during life. In humans, less than 400 of the more than 400,000 follicles found at puberty will eventually ovulate whereas the overwhelming majority of follicles undergo atresia. Although follicular atresia plays a critical role during the recruitment of follicles for ovulation, the exact mechanism of this process is unknown. In chicken and porcine ovaries, atretic follicles can be morphologically distinguished from their healthy counterparts of the same size. Adapting a sensitive 3′-end labeling method for DNA analysis, we identified internucleosomal cleavage of cellular DNA in atretic (but not normal) follicles of both animal species, resembling that found during programmed cell death in embryogenesis, autoimmune T-cell removal and prostate regression. The present findings provide a basis for elucidating the hormonal signals involved in the initiation of follicular atresia during follicle recruitment, reproductive aging and premature ovarian failure.

Original languageEnglish (US)
Pages (from-to)2799-2801
Number of pages3
Issue number5
StatePublished - Nov 1991

All Science Journal Classification (ASJC) codes

  • Endocrinology


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